2013 Fiscal Year Final Research Report
Development of a monitoring system of in vivo cell dynamics for therapeutic evaluation of psychiatric disorders
| Project/Area Number |
23659562
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OUCHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 臨床精神分子遺伝学 |
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| Research Abstract |
It has been reported that neural stem cells are variously changed in the process of not only normal neural growth but also neuronal degeneration occurring in neuropsychiatric disorders. Despite these findings, there was no study about the contribution of neural stem cells to the physiological and pathophysiological significance. Hence we tried to develop an in vivo monitoring system with which the dynamics of the stem cells can be visualized. Using positron emission tomography with a new gene-reporter system and amino acid transporter, we were able to make a new in vivo system for measuring live neural stem cells in vivo specifically.
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