2013 Fiscal Year Final Research Report
Development of the biomarker for suicide prediction using the methylation at the gene promoters
| Project/Area Number |
23659566
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kochi University (2013)
Hiroshima University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | DNAメチル化 / うつ病 / 自殺予測 / バイオマーカー / BDNF / SLC6A4 / 不遇な養育環境 |
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| Research Abstract |
To prevent the suicide in major depression, we measured the methylation levels at the promoter of exon I of the brain-derived neurotrophic factor, Trk B receptor, serotonin transporter (5HTT), and serotonin2c receptor gene in 50 patients with major depression and examined the possibility of the epigenetic biomarker for suicide prediction. We extracted DNA from peripheral blood and measured the methylation levels at the 149 CpGs in these 4 genes using MassARRAY system. No significant relationship between the methylation level of each CpG and the severity of suicidal idea evaluated by the Hamilton Rating Scale for Depression was found. However, there were significant correlations betweeen the methylation levels of 5HTT CpGs and the sevirity of eraly adversities evaluated by the Early TRauma Inventry. Based on these findings, it is postulated taht the methylation levels of CpGs in the 5HTT gene may be an appropriate biomarker for suicide prediction.
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[Journal Article] The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression2014
Author(s)
Okada S, Morinobu S, Fuchikami M, Segawa M, Yokomaku K, Kataoka T, Okamoto Y, Yamawaki S, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Trao T, Kokubo Y, Mimura M
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Journal Title
J psychiatric Res
Volume: 53
Pages: 47-53
Peer Reviewed
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