99mTc-labeled probes imitating antibodies

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659579
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Chiba University
• Principal Investigator: ARANO Yasushi 千葉大学, 大学院・薬学研究院, 教授 (90151167)
• Co-Investigator(Kenkyū-buntansha): UEHARA Tomoya 千葉大学, 大学院・薬学研究院, 准教授 (10323403)
• Co-Investigator(Renkei-kenkyūsha): HANAOKA Hirofumi 千葉大学, 大学院・薬学研究院, 助教 (50361390)
• Project Period (FY): 2011 – 2012
• Keywords: 分子イメージング / アイソトープ治療 / 抗体 / 比放射能

Research Abstract

Radiolabeled antibodies have been applied to molecular imaging and targeted radionuclice therapy. Since radiolabeled antibodies are administered in the presence of a large amount of non-labeled antibodies, the non-radiolabeled antibodies would inhibit the target accumulation of the radiolabeled antibodies. In this study, a new method was developed to prepare <99m>^Tc-labeled antibodies of high specific activities utilizing <99m>^Tc complexation reaction. The <99m>^Tc-labeled antibodies exhibited similar biodistribution in the presence of albumin or antibody F(ab')_2 fragment, suggesting further studies are worth pursuing for molecular imaging and targeted radionuclides therapy.