2012 Fiscal Year Final Research Report
Challenge of radionuclide therapy using successive decay type alpha emitters for advanced malignant melanoma
| Project/Area Number |
23659581
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射線 / 癌 / アイソトープ治療 / アルファ放射体 |
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| Research Abstract |
Alpha-particle emitting radionuclides are gaining attention inthe field of nuclear medicine. Because of their high linear energy transfer and the short range of alpha particles in tissues, alpha-emitters (211At, 223Ra, and 225Ac) show promise in treating tumors such as leukemia, melanoma, and bone metastases. In this study, labeling of alpha emitter to a peptide DOTA-Re(Arg11)CCMSH, which bound specifically to a receptor expressed on melanoma cells, were evaluated. Preliminary results using gamma-ray emitter 111In showed a high uptake of DOTA-Re(Arg11)CCMSH in melanoma tumors. Therapeutic studies using 225Ac and 227Th are currently underway.
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