Development of molecular target radiation therapy from molecular target imaging

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659582
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
• Co-Investigator(Kenkyū-buntansha): SAKAHARA Harumi 浜松医科大学, 医学部, 教授 (10187031) ; SAKAI Toshihiro 浜松医科大学, メディカルフォトニクス研究センター, 特任研究員 (40585098)
• Project Period (FY): 2011 – 2012
• Keywords: 放射線内用療法 / 分子標的薬 / イメージング / 放射性医薬品 / がん

Research Abstract

This study is a trial to develop a novel concept which makes molecular target drug for cancer enable radiation therapy . This concept can allow not only molecular target imaging and also molecular target radiation therapy. In this study, we use our new molecular imaging compound, PYK for EGFR-TK. This compound has a great potential for in vivo imaging for EGFR-TK. In conclusion, molecular target radiation therapy might be achieved although additional compounds are required to improve target uptake or target to non-target ratio.