Development of a risk-organ-shifting technique during radiation therapy, with gel spacer

2014 Fiscal Year Final Research Report

• Project/Area Number: 23659595
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Wakayama Medical University
• Principal Investigator: KISHI KAZUSHI 和歌山県立医科大学, 医学部, 研究員 (70254547)
• Co-Investigator(Kenkyū-buntansha): SAWADA Takahiro 和歌山県立医科大学, 先端医学研究所, 非常勤講師 (00382325) ; SAKAGUCHI Kazuya 和歌山県立医科大学, 先端医学研究所, 教授 (60178548) ; SATO Morio 和歌山県立医科大学, 医学部, 教授 (50154109) ; CHIBA Akihiro 和歌山県立医科大学, 医学部, 学内助教 (60597079)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ゲルスペーサー / 前立腺癌 / 再照射 / ヒアルロン酸

Outline of Final Research Achievements

We developed a risk organ-shifting method by a spacer gel injection between the target and the normal organ, and enabled to deliver higher dose to the target with a further decreased normal organ dose. By basic experiments including migration assay we determined several appropriate patterns of gel selection, injection site selection, combination of single or fractionated irradiation, and injection method. Clinically, we most treated patients with prostate cancer with Tomotherapy or Brachytherapy providing efficient rectal avoidance. By gel spacer injection, the mean target dose was escalated to 83Gy from 74Gy while the rectal D2cc was decreased to 45Gy from 72Gy. We also enabled the similar dose delivery in safe to post operative recurrence of the prostate cancer. Furthermore, reirradiation treatment was safely processed by the gel spacer injection providing a curative dose delivery. To date some of these were already published.

Free Research Field

放射線治療