2011 Fiscal Year Final Research Report
Development of a highly efficient, lower cellular damage gene transfer method by a spheroid formation of blood cells for regenerative medicine and cellular therapy
| Project/Area Number |
23659609
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATANO Hisako 東京大学, 医科学研究所, 特任助教 (50376620)
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| Project Period (FY) |
2011
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| Keywords | トランスレーショナルリサーチ / ウイルスベクター / 遺伝子治療 / 細胞療法 / 樹状細胞 |
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| Research Abstract |
Using a model of gene transduction into dendritic cells with recombinant adenoviral vector expressing EGFP, I developed an improved gene transfer method with spheroid formation, which avoided low efficient and/or high cellular damage through conventional methods. It could be a now method of a highly efficient, lower cellular damage gene transfer by a spheroid formation for blood cells for regenerative medicine and cellular therapy.
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