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2013 Fiscal Year Final Research Report

Development of autologous connective tissue sheet for cardiovascular organs

Research Project

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Project/Area Number 23659621
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OSAMU Sakai  京都府立医科大学, 医学部附属病院, 専攻医 (10298432)

Co-Investigator(Kenkyū-buntansha) KANDA Keiichi  京都府立医科大学, 医学(系)研究科(研究院), 講師 (60295649)
TAKAMIZAWA Keiichi  独立行政法人国立循環器病研究センター, 生体医工学部, 室員 (10163312)
Co-Investigator(Renkei-kenkyūsha) NAKAYAMA Yasuhide  独立行政法人国立循環器病研究センター, 生体医工学部, 室長 (50250262)
Project Period (FY) 2012 – 2013
Keywords自家組織 / シート状製生体組織 / 再生医療 / 組織工学 / in vivo
Research Abstract

Acryl plates were embedded in subcutaneous space of beagles for 8 weeks. The connective tissue sheets were obtained from the implants after trimming of the connective tissues and pulling out of the plates. The obtained connective tissue sheets were implanted to the atrium of the beagles. All 5 cases were patent after 1 week implantation with little thrombosis.

  • Research Products

    (40 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (37 results)

  • [Journal Article] Implantation study of small-caliber "biotube" vascular grafts in rat model2013

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Journal Title

      J Artif Organs

      Volume: 99(2) Pages: 59-65

    • Peer Reviewed
  • [Journal Article] A completely autologous valved conduit prepared in the open form of trileaflets (type VI biovalbe): mold design and valve function in vitro.2011

    • Author(s)
      Nakayama Y, Kanda K
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: 99(1) Pages: 135-141

    • Peer Reviewed
  • [Journal Article] Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture.2011

    • Author(s)
      Watanabe T, Kanda K, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: 98(1) Pages: 120-126

    • Peer Reviewed
  • [Presentation] 生体内組織形成技術を用いたバイオチューブ代用血管の開発2013

    • Author(s)
      神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20130300
  • [Presentation] バイオチューブ小口径代用血管の開発2013

    • Author(s)
      山南将志、神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20130300
  • [Presentation] バイオシートの心房修復材への応用:移植 3 ヶ月後の変化2013

    • Author(s)
      山南将志、坂井 修、神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20130300
  • [Presentation] In vitro and in vivo performance of a completely autologous aortic valved conduit (Biovalve type VII) prepared by in body tissue architecture technology using a novel separatable mold.2012

    • Author(s)
      Nakayama Y, Kanda K
    • Organizer
      Ammerican association scientific sessions
    • Place of Presentation
      LA (USA)
    • Year and Date
      20121100
  • [Presentation] バイオチューブの血液透析用シャント用代用血管への応用の可能性2012

    • Author(s)
      山南将志、神田圭一、中山泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      福岡
    • Year and Date
      20121100
  • [Presentation] バイオチューブを用いた冠動脈バイパス術-ブタでの予備的異種移植実験-2012

    • Author(s)
      渡辺太治、神田圭一、中山泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      福岡
    • Year and Date
      20121100
  • [Presentation] バイオシートの心房修復材への応用2012

    • Author(s)
      山南将志、神田圭一、中山泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      福岡
    • Year and Date
      20121100
  • [Presentation] バイオチューブ代用血管-冠動脈バイパスグラフトとしての応用-2012

    • Author(s)
      渡辺太治、中山泰秀 神田圭一
    • Organizer
      日本胸部外科学会
    • Place of Presentation
      福岡
    • Year and Date
      20121000
  • [Presentation] rapid preparation of Biotube vascular grafts by using eosin-eluting molds2012

    • Author(s)
      Watanabe T, Kanda K, Nakayama Y
    • Organizer
      XXXIX ESAO congress.
    • Place of Presentation
      Rostock (Germany)
    • Year and Date
      20120900
  • [Presentation] Biotube application to the arteriovenous shunt2012

    • Author(s)
      Yamanami M, Kanda K Nakayama Y.
    • Organizer
      XXXIX ESAO congress.
    • Place of Presentation
      Rostock (Germany)
    • Year and Date
      20120900
  • [Presentation] First report of application of Biotube vascular graft to off-pump CABG in an acute porcine model.2012

    • Author(s)
      Watanabe T, Kanda K, Nakayama Y
    • Organizer
      XXXIX ESAO congress.
    • Place of Presentation
      Rostock (Germany)
    • Year and Date
      20120900
  • [Presentation] Development of autologous tissue small caliber vascular grafts (Biotubes).2012

    • Author(s)
      Yamanami M, Kanda K Nakayama Y
    • Organizer
      ESC congress.
    • Place of Presentation
      Munich (Germany)
    • Year and Date
      20120800
  • [Presentation] 患者の体内で自家移植用臓器を作製し、移植後急速な再生組織構築を誘導する『生体内組織形成技術』の開発2012

    • Author(s)
      神田圭一、中山泰秀
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20120600
  • [Presentation] 生体内組織形成術:自分の移植臓器を自分の体内で作れる新技術2012

    • Author(s)
      中山泰秀 神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20120600
  • [Presentation] バイオバルブ心臓弁の生体内形成過程のカプセル内視鏡観察2012

    • Author(s)
      中山泰秀 神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20120600
  • [Presentation] 生体内組織形成術による循環器系再生医療デバイスの開発2012

    • Author(s)
      山南将志、中山泰秀 神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20120600
  • [Presentation] バイオチューブ短期作製のための工夫2012

    • Author(s)
      渡辺太治、中山泰秀 神田圭一
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      20120600
  • [Presentation] Successful replacement of beagle pulmonary valves by in vitro tissue-engineered valved-conduits with the sinus of valsalva2012

    • Author(s)
      Yamanami M, Kanda K Nakayama Y
    • Organizer
      61th ESCVS
    • Place of Presentation
      Croatia
    • Year and Date
      20120500
  • [Presentation] 自家結合組織のみからなり宿主生体内で簡便に形成される、小口径代用血管バイオチューブの開発2012

    • Author(s)
      神田圭一、坂井 修、中山泰秀
    • Organizer
      日本外科学会
    • Place of Presentation
      幕張
    • Year and Date
      20120400
  • [Presentation] カプセル内視鏡内臓鋳型を用いた体内組織形成過程の in situ 観察2011

    • Author(s)
      中山泰秀、神田圭一
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      東京
    • Year and Date
      20111100
  • [Presentation] バイオチューブ小口径代用血管の固定処理:吻合操作性の向上と自己化の維持2011

    • Author(s)
      山南将志、神田圭一、中山泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      東京
    • Year and Date
      20111100
  • [Presentation] インスタントバイオチューブ:エオシン徐放化鋳型による肉厚バイオチューブの短期形成2011

    • Author(s)
      渡辺太治、神田圭一、中山泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      東京
    • Year and Date
      20111100
  • [Presentation] Architecture design of a novel separable mold to obtain autologous tissue heart valves "Biovalves" non-invasively.2011

    • Author(s)
      Nakayama Y, Kanda K
    • Organizer
      ESAO-IFAO congress
    • Place of Presentation
      Porto (Portugal)
    • Year and Date
      20111000
  • [Presentation] 6-month auto-implantation of autologous tissue small-caliber vascular grafts, "Biotube", to carotid arteries of the beagle dogs2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Organizer
      ESAO-IFAO congress
    • Place of Presentation
      Porto (Portugal)
    • Year and Date
      20111000
  • [Presentation] Development of a small-caliber autologous vascular graft Biotube; four-year animal implantation.2011

    • Author(s)
      Watanabe T, Kanda K, Nakayama Y
    • Organizer
      ESAO-IFAO congress
    • Place of Presentation
      Porto (Portugal)
    • Year and Date
      20111000
  • [Presentation] Preparation of a completely autologous valved conduit with the open form of trileaflets (Type VI Biovalve).2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Organizer
      ESAO-IFAO congress
    • Place of Presentation
      Porto (Portugal)
    • Year and Date
      20111000
  • [Presentation] Feasibility study of in-body tissueengineered, completely autologous valved conduits (Biovalves type IV) as an aortic valve in a goat model.2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y.
    • Organizer
      ESC congress
    • Place of Presentation
      Paris (France)
    • Year and Date
      20110800
  • [Presentation] Yamanami M, Kanda K, Nakayama Y2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Organizer
      ESC congress
    • Place of Presentation
      Paris (France)
    • Year and Date
      20110800
  • [Presentation] 生体内組織形成技術を用いた自家移植用循環器系移植片の開発2011

    • Author(s)
      山南将志、神田圭一、中山泰秀
    • Organizer
      日本小児心血管分子医学研究会
    • Place of Presentation
      福岡
    • Year and Date
      20110700
  • [Presentation] バイオバルブの開発:作製鋳型の変遷2011

    • Author(s)
      中山泰秀、神田圭一
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      20110600
  • [Presentation] 体内光照射によるエラスチン含有高肥厚バイオチューブ人工血管の作製2011

    • Author(s)
      中山泰秀、神田圭一
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      20110600
  • [Presentation] 完全自己組織からなる心臓弁様組織体バイオバルブ(Type VI)の開発:開口形状での弁形成による弁機能の向上2011

    • Author(s)
      山南将志、神田圭一、中山泰秀
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      20110600
  • [Presentation] Development of autologous tissue small caliber vascular grafts (Biotubes) constructed by simple, safe and economical in vivo tissue engineering2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Organizer
      ESCVS
    • Place of Presentation
      Moscow (Russia)
    • Year and Date
      20110500
  • [Presentation] Successful replacement of beagle pulmonary valves by in vivo tissue-engineered valved-conduits eith the sinus of valsalva "Biovalves".2011

    • Author(s)
      Yamanami M, Kanda K, Nakayama Y
    • Organizer
      ESCVS
    • Place of Presentation
      Moscow (Russia)
    • Year and Date
      20110500
  • [Presentation] 生体内組織形成技術を用いた小口径代用血管 "Biotube"の開発2011

    • Author(s)
      山南将志、坂井 修、神田圭一、中山泰秀
    • Organizer
      日本血管外科学会
    • Place of Presentation
      沖縄
    • Year and Date
      20110400
  • [Presentation] バイオバルブ大動脈弁(Type VII)の開発

    • Author(s)
      中山泰秀、神田圭一
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      福岡
  • [Presentation] 宿主体内で形成する自家組織結合組織小口径代用血管バイオチューブの開発

    • Author(s)
      渡辺太治、神田圭一、中山泰秀
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都

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Published: 2014-09-25  

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