2012 Fiscal Year Final Research Report
Anchorage-independent growth and EMT relationship in esophageal cancer.
| Project/Area Number |
23659637
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Tetsuro 千葉大学, 医学部附属病院, 医員 (30645586)
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| Research Collaborator |
TAMURA Yutaka 千葉大学, 大学院・医学研究院, 准教授 (50263174)
AKANUMA Naoki 千葉大学, 医学部附属病院, 医員 (70645598)
MARUYAMA Tetsuro 千葉大学, 医学部附属病院, 医員 (30645586)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食道癌 / 足場非依存的増殖 / Fra-1 / 浸潤能 / invadepodia |
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| Research Abstract |
ra-1 is reported one of key molecule inducing anchorage-independent growth that is related to invasion and metastasis in cancer cells. I investigated the role of this molecule in esophageal squamous cell carcinoma (ESCC). I clarified Fra-1 is an important molecule in progression in ESCC. Furthermore, Fascin is also associated with poor prognosis. And Fascin is also related to invasion and metastasis in cancer cells.
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[Journal Article] miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1.2012
Author(s)
Takeshita N, Mori M, Kano M,Hoshino I, Akutsu Y, Hanari N,Yoneyama Y, Ikeda N, Isozaki Y, Maruyama T, Akanuma N, Miyazawa Y,Matsubara H.
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Journal Title
Int J Oncol.
Volume: Nov;41(5)
Pages: 1653-61
DOI
Peer Reviewed
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