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2012 Fiscal Year Final Research Report

A novel approach for early diagnosis and personalized therapy to pancreatic cancer by metabolic profiling

Research Project

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Project/Area Number 23659654
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

MIZUMOTO Kazuhiro  九州大学, 大学病院, 准教授 (90253418)

Co-Investigator(Kenkyū-buntansha) ONIMARU Manabu  九州大学, 医学研究院, 共同研究員 (80529876)
INOUE Shigetaka  九州大学, 医学研究院, 共同研究員 (00529802)
Project Period (FY) 2011 – 2012
Keywords膵癌 / 代謝産物膵癌 / 治療抵抗性 / ゲムシタビン耐性 / MALDI-IMS / 凍結組織マイクロアレイ / メタボリックプロファイリングマッピング
Research Abstract

We performed metabolic profiling analysis with two Gemcitabine resistant pancreatic cancer cell lines and their parent strains by Liquid Chromatography - tandem Mass Spectrometry , then detected variance in 30 % metabolic profiling between them. Furthermore, we also performed matrix-assisted laser desorption/ionization imaging mass spectrometry with 12 resected specimens which arrayed in frozen tissue microarray. More than 40 kinds of metabolites were identified and mapped on the each section, and interestingly some of metabolites showed different distributions between normal and tumor tissue. We will investigate these identified metabolites continuously for possibility of early diagnosis and personalized medicine.

  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] Tissue Tablet 法-新鮮凍結サンプルの新しい保存・管理法-2012

    • Author(s)
      寅田 信博、大内田 研宙 、崔 林、水元一博、相島 慎一、小田 義直、田中 雅夫
    • Organizer
      第49回九州外科
    • Place of Presentation
      佐賀市
    • Year and Date
      2012-05-18
  • [Presentation] Tissue Tablet(組織タブレット)法-手術切除組織の保存・管理のための新しいアプローチ-2012

    • Author(s)
      寅田 信博、大内田 研宙 、崔 林、水元 一博、相島 慎一、小田 義直、田中 雅夫
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-04-12

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Published: 2014-09-25  

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