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2012 Fiscal Year Final Research Report

The identification of miR-gene pathway regulating the sensitivity of platinum agentsfor gastric cancer and its clinical applicatio

Research Project

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Project/Area Number 23659656
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

BABA Hideo  熊本大学, 大学院・生命科学研究部, 教授 (20240905)

Co-Investigator(Kenkyū-buntansha) WATANABE Masayuki  熊本大学, 大学院・生命科学研究部, 准教授 (80254639)
HIRASHIMA Kotaro  熊本大学, 医学部附属病院, 非常勤診療医師 (10594468)
Project Period (FY) 2011 – 2012
Keywords塩基修復遺伝子 / 白金製剤耐性 / microRNA / 胃癌
Research Abstract

A platinum agent, cisplatin (CDDP) plus S-1 is the standard regimenfor unresectable or recurrent gastric cancer. However, grade 3/4 adverse events arefrequently observed in patients received with CDDP based regimen. Oxaliplatin (L-OHP)is a third-generation platinum compound and the non-inferiority of L-OHP-based regimensto CDDP-based regimen was demonstrated in large phase III study for esophagogastric cancer.Furthermore, L-OHP is associated with less toxicity and better tolerability, especiallyin older patients and significant survival benefit over CDDP. In the current study, weexamined the expression of the novel genes regulating the sensitivity for platinum agentsin clinical samples and whether these genes expression is associated with the sensitivityto CDDP using by clinical samples.

  • Research Products

    (18 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Phase II trial of alternatingmFOLFOX6 and FOLFIRI regimens in thefirst-line treatment for unresectableor metastatic colorectal cancer(KSCC0701).2013

    • Author(s)
      Oki E, Emi Y, Akagi Y, Tokunaga S,Sadanaga N, Tanaka T, Ogata Y, SaekiH, Kakeji Y, Baba H, Nishimaki T,Natsugoe S, Shirouzu K, Maehara Y
    • Journal Title

      Kyushu Study Group of Clinical Cancer.Oncology

      Volume: 84 Pages: 233-9

    • DOI

      DOI: 10.1159 /000346690.

    • Peer Reviewed
  • [Journal Article] Clinical impact of serum exosomalmicroRNA-21 as a clinical biomarker inhuman esophageal squamous cellcarcinoma.2013

    • Author(s)
      Tanaka Y, Kamohara H, Kinoshita K,Kurashige J, Ishimoto T, Iwatsuki M,Watanabe M, Baba H
    • Journal Title

      Cancer

      Volume: 119 Pages: 1159 -67

    • DOI

      DOI: 10.1002/cncr.27895.

    • Peer Reviewed
  • [Journal Article] Upregulation of ERCC1 and DPDexpressions after oxaliplatin-basedfirst-line chemotherapy formetastatic colorectal cancer2012

    • Author(s)
      Baba H,Watanabe M, Okabe H, Miyamoto Y,Sakamoto Y, Baba Y, Iwatsuki M,Chikamoto A, Beppu T.
    • Journal Title

      Br J Cancer

      Volume: 107 Pages: 1950-5

    • DOI

      DOI: 10.1038/bjc.2012.502.

    • Peer Reviewed
  • [Journal Article] Recent advances in diagnosis andtreatment for malignancies of thegastrointestinal tract.2012

    • Author(s)
      Watanabe M , Baba H, Ishioka C,Nishimura Y, Muto M.
    • Journal Title

      Digestion

      Volume: 85 Pages: 95-98

    • DOI

      DOI: 10.1159/000334677.

    • Peer Reviewed
  • [Journal Article] PN2 expression predicts response todocetaxel in oesophageal squamouscell carcinoma.2012

    • Author(s)
      Kurashige J, Watanabe M, Iwatsuki M,Kinoshita K, Saito S, Nagai Y,Ishimoto T, Baba Y, Mimori K, Baba H
    • Journal Title

      Br J Cancer

      Volume: 107 Pages: 1233-8

    • DOI

      DOI: 10.1038/bjc.2012.396.

    • Peer Reviewed
  • [Journal Article] Kurashige J, Kamohara H, Watanabe M,Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H2012

    • Author(s)
      MicroRNA-200 bregulates cellproliferation, invasion andmigration by directly targeting ZEB2in gastric carcinoma.
    • Journal Title

      Ann Surg Oncol

      Volume: l19 Pages: 656-64

    • DOI

      DOI: 10.1245/s10434-012-2217-6.

    • Peer Reviewed
  • [Presentation] 治癒切除不能進行・再発胃癌に対する新たな治療戦略2012

    • Author(s)
      井田 智、馬場秀夫
    • Organizer
      第28回日本消化器癌発生学会
    • Place of Presentation
      徳島県 ルネッサンスリゾートナルト
    • Year and Date
      2012-11-15
  • [Presentation] 胃癌における HER2 陽性微量癌細胞を標的とした個別化治療への応用2012

    • Author(s)
      岩槻政晃、渡邊雅之、石本崇胤、岩上志朗、馬場祥史、馬場秀夫
    • Organizer
      第67回日本消化器外科学会
    • Place of Presentation
      富山県 富山県民会館
    • Year and Date
      2012-07-18
  • [Presentation] 高齢者胃癌患者における GlasgowPrognistic Score(GPS)の検討2012

    • Author(s)
      平島浩太郎、渡邊雅之、蔵重淳二、木下浩一、齋藤誠哉、井田 智、石本崇胤、長井洋平、岩槻政晃、岩上志朗、馬場祥史、宮本裕士、別府 透、馬場秀夫
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉県 幕張メッセ国際会議場
    • Year and Date
      2012-04-14
  • [Presentation] 食道扁平上皮癌におい microRNA-223は癌抑制遺伝子ユビキチンリガーゼ複合体基質ユニット FBXW7 の発現を制御する.2012

    • Author(s)
      蔵重淳二、渡邊雅之、田中洋平、木下浩一、齋藤誠哉、岩槻政晃、馬場祥史、蒲原英伸、馬場秀夫
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉県 幕張メッセ国際会議場
    • Year and Date
      2012-04-13
  • [Presentation] Overexpression of microRNA-223regulates the ubiquitin ligase FBXW7in esophageal squamous cellcarcinoma.2012

    • Author(s)
      Kurashige J,Watanabe M, Iwatsuki M,Baba Y, Baba H
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      USA McCormick Place West
    • Year and Date
      2012-04-02
  • [Presentation] Changes in expression levels ofexcision repair cross-complementinggroup 1 (ERCC1) and dihydropyrimidinedehydrogenase (DPD) duringfirst-line oxaliplatin-basedtreatment of advanced metastaticcolorectal cancer (mCRC)2012

    • Author(s)
      Baba H, Watanabe M, Okabe H, MiyamotoY, Sakamoto Y, Baba Y, Iwatsuki M,Chikamoto A, Beppu T
    • Organizer
      ASCO GI 2012 California
    • Place of Presentation
      USA The Moscone West Building
    • Year and Date
      2012-01-19
  • [Presentation] 胃癌における microRNA-200bによる浸潤転移機構の制御2011

    • Author(s)
      藏重淳二、渡邊雅之、蒲原英伸、日吉幸晴、木下浩一、齋藤誠哉、田中洋平、岩槻政晃、馬場祥史
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県 名古屋国際会議場
    • Year and Date
      20111003-1005
  • [Presentation] 胃癌における microRNA-200b による癌浸潤転移の制御機構2011

    • Author(s)
      藏重淳二、渡邊雅之、木下浩一、齋藤誠哉、佐藤伸隆、辛島龍一、平島浩太郎、日吉幸晴、岩槻政晃、蒲原英伸、林 尚子、馬場秀夫
    • Organizer
      第111回日本外科学会定期学術集会
    • Year and Date
      20110526-0528
  • [Presentation] 胃癌における新規白金製剤耐性因子PLOB 遺伝子の発現の検討2011

    • Author(s)
      岩槻政晃、渡邊雅之、蔵重淳二、木下浩一、石本崇胤、岩上志朗、馬場祥史、馬場秀夫
    • Organizer
      第43回胃病態機能研究会
    • Place of Presentation
      大阪府 シェラトン都ホテル大阪
    • Year and Date
      2011-07-30
  • [Presentation] SPEM(spasmolytic polypeptideexpressing metaplasia)を介した胃癌発生における CD44 の役割2011

    • Author(s)
      石本崇胤、渡邊雅之、井田 智、長井洋平、岩上志朗、坂本快郎、岩槻政晃、馬場祥史、宮本裕士、和田剛幸、永野 修、佐谷秀行、馬場秀夫
    • Organizer
      第43回胃病態機能研究会
    • Place of Presentation
      大阪府 シェラトン都ホテル大阪
    • Year and Date
      2011-07-30
  • [Presentation] 胃癌化学療法における新規白金製剤耐性因子の同定2011

    • Author(s)
      岩槻政晃、渡邊雅之、岩上志朗、馬場祥史、林 尚子、三森功士、森 正樹、馬場秀夫
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      愛知県 名古屋国際会議場
    • Year and Date
      2011-07-04
  • [Presentation] 胃癌における microRNA-200bによる浸潤転移機構の制御2011

    • Author(s)
      蔵重淳二、渡邊雅之、田中洋平、木下浩一、齋藤誠哉、日吉幸晴、岩槻政晃、馬場祥史、馬場秀夫
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      静岡県 アクトシティ浜松 コングレスセンター
    • Year and Date
      2011-07-01

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Published: 2014-09-25  

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