2012 Fiscal Year Final Research Report
Exploration of carbohydrate molecular markers for biliary tract cancers by carbohydrate profiling.
| Project/Area Number |
23659659
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIIZUMI Syunnichi 東京女子医科大学, 医学部, 講師 (40277158)
OHTA Takehiro 東京女子医科大学, 医学部, 講師 (70203792)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肝内胆管癌 / バイオマーカー / 糖鎖医学 / レクチン / 胆道癌モデル |
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| Research Abstract |
As a result of tissue-targeted lectin microarray analysis, we found that Wisteria floribunda agglutinin (WFA) is the best probe to differentiate biliary tract cancer lesions from normal bile duct epithelia (BDE) (P < 0.0001). The subsequent histochemical study confirmed cancer-specific WFA staining on the tissue specimens. Furthermore, the results of the experiments strongly implied that sialylated MUC1 is a candidate glycoprotein that carries biliary tract cancer-associated, WFA-reactive glycans. Therefore, we developed a new WFA-MY.1E12 sandwich detection ELISA that is a highly sensitive diagnostic method for biliary tract cancers using bile specimens. The diagnostic sensitivity of WFA-MY.1E12 for the detection of biliary tract cancers were found to be superior to that of CA19-9
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
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Journal Title
J Gastroenterol
Volume: (In press)
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[Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, OnoderaM, Nakanuma Y, Yamato M, Yamamoto M, Hyodo I, Shoda J.
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
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[Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas2011
Author(s)
Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M.
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Journal Title
Gut
Volume: 60
Pages: 509-16
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[Presentation] 左三区域切除兼肝外胆道切除にて切除し得た Binf 陽性胆嚢癌の1例2012
Author(s)
樋口亮太,梶山英樹,谷澤武久,小貫建一郎,植村修一郎,濱野美枝,竹下信啓,古川 徹,太田岳洋,新井田達雄,山本雅一
Organizer
第48回日本胆道学会学術集会
Place of Presentation
東京
Year and Date
20120000
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