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2012 Fiscal Year Final Research Report

Elucidation of the rupture mechanism By immunohistological analysis and computed fluid dynamics analysis according to the aneurysmal wall proparties in human ruptured cerebral aneurysm.

Research Project

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Project/Area Number 23659678
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionHokkaido University

Principal Investigator

NAKAYAMA Naoki  北海道大学, 北海道大学病院, 助教 (40421961)

Co-Investigator(Kenkyū-buntansha) MORIWAKI Takuya  北海道大学, 大学院・医学研究科, 非常勤講 師 (30597464)
HOUKIN Kiyohiro  北海道大学, 大学院・医学研究科, 教授 (90229146)
Project Period (FY) 2011 – 2012
Keywords脳血管障害学 / 脳動脈瘤 / 破裂 / 内皮 / 炎症 / 免疫染色 / computed flow dynamics
Research Abstract

Aneurysmal specimens in human clinical cases totaled 54 (ruptured 40, non-ruptured 14), which were obtained after clipping surgery, were acquired till now. As findings to be characteristic of ruptured cerebral aneurysm, <1> fibrin deposition under aneurysm endothelium, <2> infiltration of inflammatory cell to intima, <3> layered thrombus formation in inside wall surface were found.On the other hand, by immunohistological study and scanning electron microscopic study, endothelial cell seems to be still present in an aneurysm inside wall while a function falls. But, especially in ruptured aneurysm, it is speculated that its configuration and alignment was distracted, or it had been lost. When it considers from these findings, aneurysm may rupture because wall disintegration gets up by thrombus formation in intima and intramural bleeding and drastic inflammatory reaction following the endothelium disorder that was influenced by mechanical stress.

  • Research Products

    (3 results)

All 2012

All Presentation (3 results)

  • [Presentation] 嚢状脳動脈瘤の病理像 -動脈瘤壁の炎症と血管内皮細胞下のフィブリン析出が脳動脈瘤破裂に与える影響について2012

    • Author(s)
      穂刈正明、中山若樹、西原広史、寳金清博
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2012-10-17
  • [Presentation] 嚢状脳動脈瘤の病理像 -動脈瘤壁の炎症 と血管内皮細胞下のフィブリン析出が脳 動脈瘤破裂に与える影響について2012

    • Author(s)
      穂刈正明、中山若樹、西原広史、寳金清博
    • Organizer
      北海道脳卒中研究会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2012-07-07
  • [Presentation] 嚢状脳動脈瘤の病理像-動脈瘤壁の炎症と血管内皮細胞下のフィブリン析出が脳 動脈瘤破裂に与える影響について2012

    • Author(s)
      穂刈正明、中山若樹、西原広史、寳金清博
    • Organizer
      日本脳卒中の外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-04-26

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Published: 2014-09-25  

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