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2012 Fiscal Year Final Research Report

Imaging of motion dynamics of cerebral aneurysms using 4DCTA

Research Project

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Project/Area Number 23659684
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

KURODA Junko  大阪大学, 医学系研究科, 特任研究員 (00528391)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Manabu  大阪大学, 医学系研究科, 助教 (40448064)
FUJINAKA Toshiyuki  大阪大学, 医学系研究科, 助教 (00359845)
Project Period (FY) 2011 – 2012
KeywordsCTA / 未破裂脳動脈
Research Abstract

We aimed to elucidate the motion dynamics of unruptured cerebral aneurysm during the cardiac cycle by analyzing 4-dimentional CT angiography data. We were able to confirm that cerebral aneurysms show a two-peak volume change during a cardiac cycle and that the relative volume change during this cycle does not differ from that of normal cerebral arterial vessels.

  • Research Products

    (42 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (26 results)

  • [Journal Article] Novel PET imaging index, 18F-fluorodeoxy glucose/11C-methionine uptake decoupling score, reflects glioma cell infiltration.2012

    • Author(s)
      Kinoshita M, Arita H, Goto T, Okita Y, Isohashi K, Watabe T, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
    • Journal Title

      J Nucl Med.

      Volume: 53(11) Pages: 1701-1708

    • DOI

      DOI:10.2967/jnumed.112.104992

    • Peer Reviewed
  • [Journal Article] Biological characteristics of growth hormone-producing pituitary adenoma are different according to responsiveness to thyrotropin-releasing hormone.2012

    • Author(s)
      Arita H, Kinoshita M, Oshino S, Kitamura T, Otsuki M, Kasayama S, Shimorura I, Yoshimine T, Saitoh Y
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 97(8) Pages: 2741-2747

    • DOI

      DOI:10.1210/jc.2012-1125

    • Peer Reviewed
  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma.2012

    • Author(s)
      Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T
    • Journal Title

      J Neurosurg.

      Volume: 116(4) Pages: 835-842

    • DOI

      DOI:10.3171/2011.12.JNS111255

    • Peer Reviewed
  • [Journal Article] Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron emission tomography.2012

    • Author(s)
      Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Isohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
    • Journal Title

      J Neuro-oncol.

      Volume: 107(2) Pages: 379-386

    • DOI

      DOI:10.1007/s11060-011-0759-2

    • Peer Reviewed
  • [Journal Article] CD166/Activated leukocyte cell adhesion molecule (ALCAM) is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion.2012

    • Author(s)
      Kijima N, Hosen N, Kagawa N, Hashimoto N, Nakano A, Fujimoto Y, Kinoshita M, Sugiyama H, Yoshimine T
    • Journal Title

      Neuro-oncology

      Volume: 14(10) Pages: 1254-1264

    • DOI

      DOI:10.3171/2011.11.JNS11999

    • Peer Reviewed
  • [Journal Article] Cardiac-cycle related volume change in unruptured cerebral aneurysms: a detailed volume quantification study using 4DCTA.2012

    • Author(s)
      Kuroda J, Kinoshita M, Tanaka H, Nishida T, Nakamura H, Watanabe Y, Tomiyama N, Fujinaka T, Yoshimine T
    • Journal Title

      Stroke.

      Volume: 43(1) Pages: 61-66

    • DOI

      DOI:10.1161/STROKEAHA.111.626846

    • Peer Reviewed
  • [Journal Article] Management of aneurysmal subarachnoid hemorrhage2012

    • Author(s)
      Fujinaka T, Yoshimine T, Mashimo T
    • Journal Title

      Masui

      Volume: 61(9) Pages: 962-972

    • URL

      http://mol.medicalonline.jp/library/archive/search?jo=ad3msuie&vo=61&nu=9

    • Peer Reviewed
  • [Journal Article] 11C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.2012

    • Author(s)
      Arita H, Kinoshita M, Kagawa N, Fujimoto Y, Kishima H, Hashimoto N, Yoshimine T
    • Journal Title

      Cancer

      Volume: 118(6) Pages: 1619-1627

    • DOI

      DOI:10.1002/cncr.26445.

    • Peer Reviewed
  • [Journal Article] Imaging18F-fluorodeoxy glucose/11C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema.2012

    • Author(s)
      Kinoshita M, Goto T, Arita H, Okita Y, Ishohashi K, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Saitoh Y, Hatazawa J, Hashimoto N, Yoshimine T
    • Journal Title

      J Neuro-oncol

      Volume: 106(2) Pages: 417-425

    • DOI

      DOI:10.1007/s11060-011-0688-0

    • Peer Reviewed
  • [Journal Article] Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies.2012

    • Author(s)
      Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, Morii E, Kishima H, Maruno M, Kato A, Yoshimine T
    • Journal Title

      J Neurosurg

      Pages: 574-580

    • DOI

      DOI:10.3171/2011.11.JNS11999

    • Peer Reviewed
  • [Journal Article] Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.2012

    • Author(s)
      Fujimoto Y, Hashimoto N, Kinoshita M, Miyazaki Y, Tanaka S, Yakushijin T, Takehara T, Kagawa N, Yoshimine T
    • Journal Title

      Int J Clin Oncol

      Pages: 290-293

    • DOI

      DOI:10.1007/s10147-011-0294-3

    • Peer Reviewed
  • [Journal Article] Significance of Tumor Volume Related to Peritumoral Edema in Intracranial Meningioma Treated with Extreme Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions.2011

    • Author(s)
      Morimoto M, Yoshioka Y, Shiomi H, Isohashi F, Konishi K, Kotsuma T, Fukuda S, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T, Koizumi M
    • Journal Title

      Jpn J Clin Oncol

      Pages: 609-616

    • DOI

      DOI10.1093/jjco/hyr022

    • Peer Reviewed
  • [Journal Article] Quantification of cerebral artery motion during the cardiac cycle2011

    • Author(s)
      Nishida T, Kinoshita M, Tanaka H, Fujinaka T, Yoshimine T
    • Journal Title

      Am J Neuroradiol

      Volume: 32(11) Pages: E206-208

    • DOI

      DOI:10.3174/ajnr.A2354

    • Peer Reviewed
  • [Journal Article] Radiation-induced Anaplastic Ependymoma with a Remarkable Clinical Response to Temozolomide: A Case Report.

    • Author(s)
      Khoo HM, Kishima H, Kinoshita M, Goto Y, Kagawa N, Hashimoto N, Maruno M, Yoshimine T
    • Journal Title

      Br J Neurosurg.

      Volume: (in press)

    • DOI

      DOI:10.3109/02688697.2012.741740

    • Peer Reviewed
  • [Journal Article] Training for the acquisition of psychomotor skills for endoscopic endonasal surgery using a personal webcam trainer

    • Author(s)
      Hirayama R, Fujimoto Y, Umegaki M, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T
    • Journal Title

      J Neurosurg.

      Volume: (in press)

    • DOI

      DOI:10.3171/2012.12.JNS12908.

    • Peer Reviewed
  • [Journal Article] Prevalence of cerebral aneurysm in patients with acromegaly

    • Author(s)
      Oshino S, Nishino A, Suzuki T, Arita H, Tateishi A, Matsumoto K, Shimokawa T, Kinoshita M, Yoshimine T, Saitoh Y
    • Journal Title

      Pituitary.

      Volume: (in press)

    • DOI

      DOI:10.1007/s11102-012-0404-x

    • Peer Reviewed
  • [Presentation] 大型血栓化脳動脈瘤の治療:血管内治療の成績と問題点2013

    • Author(s)
      藤中俊之
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      愛知
    • Year and Date
      2013-03-23
  • [Presentation] 頭頚部血管解離に対するステントを用いた血管内治療2013

    • Author(s)
      藤中俊之
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      愛知
    • Year and Date
      2013-03-23
  • [Presentation] 4D 造影 C による機能性微小下垂体腺腫の局在診断と造影効果の動態解析2013

    • Author(s)
      木下 学
    • Organizer
      第23回日本間脳下垂体腫瘍学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-16
  • [Presentation] 外傷性頭頚部血管損傷に対する血管内治療の有用性2013

    • Author(s)
      藤中俊之
    • Organizer
      第36回日本脳神経外傷学会
    • Place of Presentation
      愛知
    • Year and Date
      2013-03-08
  • [Presentation] ボクシングの試合中に受傷した急性硬膜下血腫の一例2013

    • Author(s)
      黒田淳子
    • Organizer
      第36回日本脳神経外傷学会
    • Place of Presentation
      愛知
    • Year and Date
      2013-03-08
  • [Presentation] Affibody-SPIO による MR 分子イメージング2012

    • Author(s)
      木下 学
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-25
  • [Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET-COMPARISON OF 11C-METHIONINE, FDG PET, AND 11C-METHIONINE/FDG DECOUPLING SCORE2012

    • Author(s)
      Kinoshita Manabu
    • Organizer
      17th Annual Scientific Meeting of Society for NeuroOncology.
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-11-17
  • [Presentation] FDG/11C-methionine PET 非同期度による非造影グリオーマのグレード判別2012

    • Author(s)
      木下 学
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-19
  • [Presentation] 外傷性頭頚部血管損傷の診断と治療-CTA によるスクリーニングと血管内治療について-2012

    • Author(s)
      藤中俊之
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-19
  • [Presentation] マルチモダリティナビゲーションガイド下定位的組織採取のための解析ソフトウェア開発2012

    • Author(s)
      木下 学
    • Organizer
      第64回日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-15
  • [Presentation] 中大脳動脈瘤に対するコイル塞栓術の治療成績2012

    • Author(s)
      黒田淳子
    • Organizer
      第13回近畿脳神経血管内治療学会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-09-08
  • [Presentation] マルチモダリティナビゲーションガイド下定位的組織採取のための解析ソフトウェア開発2012

    • Author(s)
      木下 学
    • Organizer
      第64回日本脳神経外科学会 近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-01
  • [Presentation] 11C-methionine PET parametric response map, but not conventional MRI, corresponds to treatment response of WT1 immunotherapy for recurrent malignant glioma.2012

    • Author(s)
      Kinoshita Manabu
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 20th Scientific Meeting
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-05-05
  • [Presentation] 脳動脈瘤に対するコイル塞栓術の流体力学的検討2012

    • Author(s)
      黒田淳子
    • Organizer
      第35回日本脳神経CI学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-03-02
  • [Presentation] 未破裂脳動脈瘤の心拍による体積変化の4次元的定量評価2012

    • Author(s)
      黒田淳子
    • Organizer
      第35回日本脳神経CI学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-03-02
  • [Presentation] IgG4関連下垂体炎と下垂体を標的としない頭蓋内IgG4関連疾患の違い2012

    • Author(s)
      木下 学
    • Organizer
      第22回日本間脳下垂体腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-24
  • [Presentation] 非造影グリオーマ病変ではFDG/11C-methionine PET 非同期度が腫瘍細胞密度を反映する2011

    • Author(s)
      木下 学
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-28
  • [Presentation] 頭頚部腫瘍ならびに外傷性血管損傷に対する血管内治療2011

    • Author(s)
      藤中俊之
    • Organizer
      第27回日本神経 血管内 治療学会学術 総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-26
  • [Presentation] 中大脳動脈瘤に対するコイル塞栓術の治療成績2011

    • Author(s)
      黒田淳子
    • Organizer
      第27回日本神経 血管内 治療学会学術 総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-11-26
  • [Presentation] Voxel-wise analysis of FDG and 11C-methionine PET can accurately detect glioma infiltration in the MR T2-hyper-intense area.2011

    • Author(s)
      Kinoshita Manabu
    • Organizer
      16th Annual Scientific Meeting of Society for NeuroOncology.
    • Place of Presentation
      California, USA
    • Year and Date
      2011-11-18
  • [Presentation] FDG/11C-methionine PET非同期度解析はグリオーマの脳組織浸潤度の定量的評価を可能にする2011

    • Author(s)
      木下 学
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
  • [Presentation] 未破裂脳動脈瘤の心拍による体積変化の4次元的定量評価2011

    • Author(s)
      黒田淳子
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
  • [Presentation] 部分血栓化大型脳動脈瘤の治療:血管内治療の成績と問題点2011

    • Author(s)
      藤中俊之
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
  • [Presentation] 頭頚部血管解離に対するステントを用いた血管内治療2011

    • Author(s)
      藤中俊之
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-12
  • [Presentation] 320 列 MDCT による頭蓋内血管の拍動性運動の定量的測定と解析法の開発2011

    • Author(s)
      木下 学
    • Organizer
      第36回 日本脳卒中学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-31
  • [Presentation] Segmentation of tumor infiltrative and vasogenic edema in brain tumors using voxel-wise analysis of 11C-methinonine and FDG PET and its comparison with diffusion tensor imaging.2011

    • Author(s)
      Kinoshita Manabu
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 19th Scientific Meeting
    • Place of Presentation
      Montreal, Cacada
    • Year and Date
      2011-05-09

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Published: 2014-09-25  

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