2012 Fiscal Year Final Research Report
Effect of abnormalities in asymmetric cell divisions of neural stem cells on brain tumor initiation
| Project/Area Number |
23659690
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
SHIMIZU Keiji 高知大学, 教育研究部医療学系, 教授 (70116044)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAWATA Toshio 高知大学, 教育研究部・医療学系, 助教 (40380323)
HIGASHI Yoichiro 高知大学, 教育研究部・医療学系, 助教 (80380062)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 脳腫瘍 / エピジェネティクス / 分化 |
|---|
| Research Abstract |
A method for distinguishing a stem cell from a differentiated cell using stemness gene’s promoter was developed to examine the abnormal asymmetrical cell division in malignant glioma cell cultures and tissues. By flow cytometric analysis using stem and precursor cell markers, it was revealed that glioma stem and precursor cells over-expressed MDR1 (multiple drug resistance 1) and exhibited low susceptibility to DNA damage by anti-cancer drugs.
|
Research Products
(20 results)
