Human brain activity associated with painful stimulationin patients with knee osteoarthritis. A Functional MRI Study

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659726
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: ADACHI Nobuo 広島大学, 病院, 准教授 (30294383)
• Co-Investigator(Kenkyū-buntansha): OCHI Mitsuo 広島大学, 大学院・医歯薬保健学研究院, 教授 (70177244) ; DEIE Masataka 広島大学, 大学院・医歯薬保健学研究院, 教授 (30363063)
• Project Period (FY): 2011 – 2012
• Keywords: 変形性膝関節症 / 機能的磁気共鳴画像 / 慢性疼痛 / 前頭前野背外側部

Research Abstract

Our main finding was shows a significant activate of Doroso lateral prefrontal cortex (DLPFC) in OA groups rather than normal subjects, and DLPFC activation has strong connection with pain matrix in normal subjects rather than OA groups． It is known that DLPFC function has related pain modulation． It seems that DLPFC exerts active control on pain perception by modulation corticosubcortical and corticocortical pathway in OA patient．