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2013 Fiscal Year Final Research Report

Precision surface machining to bearing surface of artificial joint

Research Project

  • PDF
Project/Area Number 23659728
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKumamoto University

Principal Investigator

NAKANISHI Yoshitaka  熊本大学, 大学院自然科学研究科, 教授 (90304740)

Co-Investigator(Kenkyū-buntansha) MIURA Hiromasa  愛媛大学, 大学院医学研究科, 教授 (10239189)
Co-Investigator(Renkei-kenkyūsha) TOUGE Mutsumi  熊本大学, 大学院自然科学研究科, 教授 (00107731)
KISHIMOTO Junji  九州大学, 医学部付属病院, 准教授 (00317322)
Project Period (FY) 2011 – 2013
Keywordsテクスチャリング / ポリエチレン / 人工関節 / 合金 / 摩耗 / 生体反応 / 研磨 / ラッピング
Research Abstract

Ultra-high molecular weight polyethylene (UHMWPE) is widely used as bearing material in a polymer-on-hard joint prosthesis; however, the wear particles are considered to be a major factor in long-term osteolysis and loosening of implants. Although the generally used surface on Co-Cr-Mo alloy for a conventional joint has 10-20 nanometer roughness, the new surface on the alloy with finishing through the precision machining has 1-2 nanometer roughness scattered concavo-shapes. The precision surface machining method is a kind of the typical lapping method, but relationship between slurry and machining surface had been strictly controlled. The new surface reduced the amount of UHMWPE wear, which would ensure the long-term durability of joints. The new surface enlarged the size of UHMWPE particles. Cells were cultured with the particles. The wear particles generated on the new surface inhibited the production of IL-6.

  • Research Products

    (6 results)

All 2014 2013 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 人工関節の表面研磨法が摩耗粉とサイトカイン産生に与える影響2013

    • Author(s)
      中西義孝、日垣秀彦、三浦裕正、水田博志、岩本幸英
    • Journal Title

      臨床バイオメカニクス

      Volume: 34巻 Pages: 11-18

    • Peer Reviewed
  • [Journal Article] 人工関節の表面テクスチャリングが高分子量ポリエチレンの摩耗に及ぼす影響2011

    • Author(s)
      松浦達己、中西義孝、日垣秀彦、白石義孝、梅野貴俊、下戸健、石川篤、三浦裕正、岩本幸英
    • Journal Title

      臨床バイオメカニクス

      Volume: 32巻 Pages: 225-230

    • Peer Reviewed
  • [Presentation] Bearing surface with nanometer geometry inhibits macrophage activation in joint prostheses2013

    • Author(s)
      Y. Nakanishi, 他
    • Organizer
      5^<th> Int. Conf. Mechanics of Biomat. and Tissues
    • Place of Presentation
      Sitges, Spain
    • Year and Date
      2013-12-08
  • [Presentation] Bearng surface with nano-level geometry inhibits macrophase activation in joint prostheses2013

    • Author(s)
      Y. Nakanishi, 他
    • Organizer
      The 15^<th> Int. Conf. Biomedical Eng. (ICBME 2013)
    • Place of Presentation
      National Unversity of Singapore, Singapore
    • Year and Date
      2013-12-04
  • [Book] Hydrated Materials.Applications in Biomedicine and Environment2014

    • Author(s)
      Y. Nakanishi
    • Total Pages
      350
    • Publisher
      Pan Stanford Publishing
  • [Remarks]

    • URL

      http://www.mech.kumamoto-u.ac.jp/Info/lab/biomech/Welcome.html

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Published: 2015-06-25  

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