Maximum respiratory variation of RR interval predicts fluid responsiveness

2014 Fiscal Year Final Research Report

• Project/Area Number: 23659739
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MORITA Koji 浜松医科大学, 医学部附属病院, 助教 (30115513)
• Co-Investigator(Kenkyū-buntansha): SANO Hideki 浜松医科大学, 医学部, 助教 (00377748)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: fluid responsiveness / RR interval variation / pulse pressure variation / plethysmo-variation

Outline of Final Research Achievements

Appropriate timing of the fluid expansion may be determined by a CVP and respiratory variation of both by a pulse pressure of ABP(PPV) and by a plethysmography(POPV). In this study, we investigated a respiratory variation of RR interval(RRV) could be used for determining the requisite of starting fluid infusion for the patient in hypovolemia state. 6 swine were administered fluid of 10% of their blood volume first and secondly 20% of thier blood volume was drained. This step was repeated 3 times and at end of each step RRV, PPV, and POPV were measured. The positive fluid responsivess is defined that cardiac output increased more than 15% after 10% of fluid infusion. The provability of responder was estimated by plotting RRV, PPV, and POPV on receiver operating curve. They were0.548, 0.489, and 0.533 respectively. We conclude RRV can predict fluid responsiveness like as PPV and POPV.

Free Research Field

biomedical sciences