2013 Fiscal Year Final Research Report
Adbanced therapy for liver fibrosis and cirrhosis by adipose derived mesenchymal stem cell
| Project/Area Number |
23659847
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKAHOSHI Tomohiko 九州大学, 大学院医学研究院, 講師 (20336019)
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| Co-Investigator(Renkei-kenkyūsha) |
MURATA Masaharu 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744)
TOMIKAWA Morimasa 九州大学, 病院先端医工学診療部, 准教授 (60325454)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肝硬変 / 脂肪由来幹細胞 / HGF |
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| Research Abstract |
Liverfibrosis was introduced into rats by repeated carbon tetrachloride intraperitoneal injections. After 6 weeks ccl4 injection, rats received splenectomy operation, PKH26 labelled ADSCs were transplanted into hepatic cirrhosis rats through the caudal vein. PKH26 staining indicated migrated ADSCs existing at liver fibrotic area, with strong expression of hepatocyte growth factor (HGF) shown by anti-HGF antibodies. Three days after ADSCs transplantation, liver function and fibrosis had ameliorated, as compared to rats treated with CCl4 alone.Conclusions: This findings indicates ADSCs transplantation is a valuable method for the therapy of hepatic fibrosis.
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[Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation2013
Author(s)
Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
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Journal Title
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[Journal Article] Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy : an evaluation using a questionnaire mailed to the patients2012
Author(s)
Tomikawa M, Korenaga D, Akahoshi T,Kohshi K, Sugimachi K, Nagao Y, Tsutsumi N, Takenaka K, Kakeji Y, Hashizume M, Maehara Y
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Journal Title
Surg Today
Volume: 42(7)
Pages: 625-32
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[Journal Article] Liver regeneration is promoted by increasing serotonin content in rat liver with secondary biliary cirrhosis2011
Author(s)
Nagao Y, Akahoshi T(Corresponding author), Kamori M, Uehara H, Hashimoto N, Kinjo N, Shirabe K, Taketomi A, Tomikawa M, Hashizume M, Maehara Y
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Journal Title
Hepatol Res
Volume: 41(8) (Epub)
Pages: 784-94
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