2012 Fiscal Year Final Research Report
Examination of signaling pathway specific to oral mucosa wound healing.- Difference between oral mucosa and epidermis -
| Project/Area Number |
23659857
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Kenji 新潟大学, 医歯学系, 准教授 (80242436)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ケラチノサイト / PI3K/Aktシグナリング / PTEN / 創傷治癒モデル / 細胞運動能 |
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| Research Abstract |
Oral mucosa heals faster than does skin, and scar formation during the wound healing in oral mucosa is also less than that in skin. We attempted to explore these differences between oral keratinocytes and epidermal keratinocytes in vitro by intrinsic cellular, biological characteristics. PI3kinase signaling pathway was activated by using a pharmacological means. Using a scratch assay (in vitro wound healing assay), cell motility and protein expressions related to PI3kinase were examined. Those reagents used in this study did not induce any significant differences.
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