2013 Fiscal Year Final Research Report
The involvement of Streptococcus anginosus infection and AID expression in oral cancers
| Project/Area Number |
23659861
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
KIMURA Shigenobu 岩手医科大学, 歯学部, 教授 (10177917)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 感染発癌 / AID / 口腔細菌 / 口腔癌 / Streptococcus anginosus |
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| Research Abstract |
Streptococcus anginosus infection could be closely related with oral squamous cellcarcinoma. Recent studies suggested that the aberrant expression of AID in the epithelial cells could re-sult in the generation of nucleotide alterations in tumor-related genes and possible malignant transforma-tion of the AID-expressing cells. In this study, the involvement of S. anginosus infection and the AID ex-pression in oral cancers was assessed. S. anginosus DNA was frequently detected in the oral squamous cell carcinoma, and the relatively higher AID expressions were observed in the cancerous region. The stimula- tion with S. anginosus antigens could induce the NF-kB activation and AID expression in cultured cell li- nes. Taken together, S. anginosus infection could be closely related with the AID expression in the oral squamous cell carcinoma.
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[Journal Article] Subcutaneous tissue reactions against nano-apatite collagen composites2012
Author(s)
Hatakeyama, W., Taira, M., Y., Kihara, H., Sasaki, M., Kimura, S., Kondo, H
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Journal Title
Nano Biomedicine
Volume: 4
Pages: 118-124
Peer Reviewed
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[Journal Article] Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions2011
Author(s)
Taira, M., Shimoyama, Y., Kagiya, T., Sasaki, M., Nezu, T., Harada, H. and Kimura, S
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Journal Title
Dent. Mater. J
Volume: 30
Pages: 293-299
Peer Reviewed
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[Presentation] Infection of 'red complex species' to the plaque of children2014
Author(s)
Shimoyama, Y., Kimura, M., Ohara-Nemoto, Y., Nemoto, T. K., Tanaka, M., Sasaki, M., Kimura, S
Organizer
第87回日本細菌学会総会
Place of Presentation
船堀,東京
Year and Date
2014-03-26
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[Presentation] The involvement of Streptococcus anginosus infection and AID expression in oral cancers2013
Author(s)
Iwasaki, K., Sasaki, M., Kodama, Y., Matsumoto, N., Kimura, S. and Sugiyama. Y
Organizer
21st International Conference on Oral and Maxillofacial Surgery
Place of Presentation
Barcelona, Spain
Year and Date
2013-10-21
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[Presentation] Distribution of Porphyromonas gingivalis fimA Genotypes in Children's plaques2013
Author(s)
Shimoyama, Y., Ohara-Nemoto, Y., Kimura, S, Sasaki, M., Kodama, Y. Tanaka,M., Kimura, S
Organizer
113^<th> General Meeting ASM
Place of Presentation
Denver, USA
Year and Date
2013-05-19
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[Presentation] The pathogenic involvement of the fibronectin binding protein, Fbp62, in Streptococcus anginosus infection2011
Author(s)
Sasaki, M., Kodama, Y., Shimoyama, Y., Agato, S. and Kimura, S
Organizer
International Union of Microbiological Societies 2011 Congress (IUMS 2011)
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-07
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[Presentation] Fbp62, fibronectin binding protein of Streptococcus anginosus involves the virulence in mouse infection2011
Author(s)
Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T. and Kimura, S
Organizer
10th World Congress on Inflammation 2011
Place of Presentation
Paris, France
Year and Date
2011-06-26
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[Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011
Author(s)
Ohara-Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S., Ono, T. and Nemoto, T.K
Organizer
111th General Meeting of the American Society for Microbiology
Place of Presentation
New Orleans, USA
Year and Date
2011-05-24
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[Presentation] Rapid identification of Abiotrophia/Granulicatella species using by 16S rRNA based PCR and RFLP2011
Author(s)
Shimoyama, Y., Sasaki, M., Ohara-Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S
Organizer
4th International Symposium for Interface Oral Health Science in Sendai
Place of Presentation
Sendai, Japan
Year and Date
2011-03-08
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[Presentation] In vitro adherence of Candida albicans to acrylic resin with different surface status2011
Author(s)
Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y., Sasaki, M. and Kimura, S
Organizer
4th International Symposium for Interface Oral Health Science in Sendai
Place of Presentation
Sendai, Japan
Year and Date
2011-03-08
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[Book] Fibronectin binding activity of Streptococcus anginosus promotes the adherence to mucosal epithelial cells. In Interface Oral Health Science 2011 (Watanabe, M. et al., eds.)2012
Author(s)
Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T. and Kimura, S
Total Pages
204-205
Publisher
Springer Japan, Tokyo
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[Book] Rapid identification of Abiotrophia/Granulicatella species using by 16S rRNA based PCR and RFLP. In Interface Oral Health Science 2011 (Watanabe, M. et al., eds.)2012
Author(s)
Shimoyama, Y., Sasaki, M., Ohara-Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S
Total Pages
206-208
Publisher
Springer Japan, Tokyo
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[Book] Maternal transmission of mutans and other oral streptococcal species. In Interface Oral Health Science 2011 (Watanabe, M. et al., eds.)2012
Author(s)
Otake-Asakawa, A., Harada-Oikawa, R., Ohara-Nemoto, Y., Tanaka, M. and Kimura, S
Total Pages
198-200
Publisher
Springer Japan, Tokyo
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[Book] In vitro adherence of Candida albicans to acrylic resin with different surface status. In Interface Oral Health Science 2011 (Watanabe, M. et al., eds.)2012
Author(s)
Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y., Sasaki, M. and Kimura, S
Total Pages
145-146
Publisher
Springer Japan, Tokyo
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