2013 Fiscal Year Final Research Report
Minimal reprogramming of cultured MSC based on DNA methylation analysis
| Project/Area Number |
23659938
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSHI Kazuto 東京大学, 医学部附属病院, 准教授 (30344451)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
MORI Yoshiyuki 東京大学, 医学部附属病院, 准教授 (70251296)
HUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医療 / 間葉系幹細胞 / DNAメチル化 |
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| Research Abstract |
The purpose of this research is to establish safe and reliable technology for regenerative medicine using the cultured mesenchymal stem cells (MSCs), which are reset by minimum reprogramming. In this research, we analyzed DNA methylation of cultured rat MSCs genome-widely, and identified the variations of methylation with cell deterioration. By using stimulus to DNA demethylation,we examined a method to improve the state of the methylation, and applied the method to a bone regeneration model in pig.
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[Presentation] OPTIMAL COMBINATIONS OF SCAFFOLDS AND GROWTH FACTORS FOR TISSUE ENGINEERING OF CARTILAGE
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[Presentation] OPTIMAL COMBINATIONS OF Innovation of Cartilage Regenerative Medicine by Implant-type Tissue-engineerd Cartilage
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[Presentation] 自己血清を軟骨再生医療の臨床展開と安 全性確保の試み
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[Presentation] Research and Development of Self-maturating Device for Cartilage Regeneration That Makes Active Use of Biological Factors in Host Environment
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[Presentation] 再生医療と生殖補助医療との相互補完は可能か-生殖補助医療の現状に学ぶ
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[Presentation] 生分解性ポリマー足場素材を用いたインプラント型再生軟骨の研究開発と臨床導入
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[Presentation] 足場素材導入による軟骨再生医療の新展開-唇裂鼻変形に対するインプラント型再生軟骨による治療
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[Presentation] DEVELOPMENT OF IMPLANT-TYPE TISSUE-ENGINEERED CARTILAGE APPLIED FOR THE CORRECTION OF THE CLEFT LIP-NOSE PATIENTS
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[Presentation] Development of implant-type tissue-engineered cartilage applied for the nasal correction of the cleft lip and palate patients
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