2013 Fiscal Year Final Research Report
Role of tumor microenviroment on invasion and metastasis of oral squamous cell carcinoma
| Project/Area Number |
23659941
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔扁平上皮癌 / 腫瘍間質 / 浸潤 / 転移 / 線維芽細胞 / 血管 / リンパ管 |
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| Research Abstract |
Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anti-fibroblastic agent and angiogenesis inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue or oral floor of nude mice, and tranilast or bevacizumab were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor size and the ratio of proliferating cell nuclear antigen positive cells were significantly reduced. The rate of metastasis in the cervical lymph node was significantly decreased. The tumor stage progression in the metastatic lymph nodes was also inhibited. The use of anticancer agent and angiogenesis inhibitor considering these effects may be clinically very useful.
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[Journal Article] xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume: 73(6)
Pages: 1855-66
DOI
Peer Reviewed
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[Journal Article] Loss of claudin-7 is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma2013
Author(s)
Yoshizawa K., Nozaki S., Kato A., Hirai M., Yanase M., Yoshimoto T., Kimura I., Sugiura .S, Okamune A., Kitahara H., Noguchi N., Kato K., Ueki K., Kawashiri S
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Journal Title
Oncology Report
Volume: 29
Pages: 445-450
DOI
Peer Reviewed
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[Presentation] Evaluation of clinical and histopathological factors for survival in squamous cell carcinoma of oral cavity2011
Author(s)
Kawashiri,S., Noguchi,N., Kato,K., Yoshizawa,K., Kitahara,H., Okamune,A., Sugiura,S., Yamamoto,E
Organizer
20th International Conference of Oral and Maxillofacial Surgery
Place of Presentation
Casa Piedra Centro de Eventos Congresos, Santiago (Chile)
Year and Date
2011-11-03
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