Control of alveolar bone metabolism activity with RAP induction andLIPUS irradiation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659959
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: IIDA Junichiro 北海道大学, 大学院・歯学研究科, 教授 (90151232)
• Co-Investigator(Renkei-kenkyūsha): SATO Yoshiaki 北海道大学, 大学院・歯学研究科, 准教授 (00250465) ; KAJII Takashi 福岡歯科大学, 歯学部, 准教授 (60322822)
• Research Collaborator: KUSAKABE Toyohisa 北海道大学, 北海道大学病院, 助教 (80322824) ; HIKONE Atsushi 北海道大学, 大学院・歯学研究科, 大学院生
• Project Period (FY): 2011 – 2012
• Keywords: 歯学細胞組織 医療 / 福祉 生理活性 歯科矯正学

Research Abstract

RAP induction method: We investigated the treatment method for increasing the activity of osteoclasts (RAP) in local alveolar bone by using a rat maxillary first molars. As a result, we confirmed that it is effective to induce RAP induction when performing osteotomy with the depth reaching bone marrow in both labial and palatal sides at for the total of six portion. (2) LIPUS irradiation conditions: We investigated the irradiation method using ultrasound (LIPUS) irradiation, expecting an increase in osteogenic activity. But we did not yet obtain significant results of changes in formation ability of alveolar bone .