2013 Fiscal Year Final Research Report
Development of caries prevention of elemental-substitution type targeted magnesium
| Project/Area Number |
23659960
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | う蝕予防 / エナメル質 |
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| Research Abstract |
Fluoride has been applied for caries prevention. Apatites included Magnesium also exist in Enamel and are easy to dissolve by acid. We developed the technique for improvement of acid resistance by replace magnesium with other chemical element.
As a result of applying thin film releasing fluoride and strontium for early caries, we observed that remineralization of early caries was promoted and the color was improved. Moreover, all forty-eight deciduous teeth applied the film did not occur the caries. From these results, the ion replace technique of enamel using fluoride and strontium is considered the pivotal method for caries prevention.
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Research Products
(6 results)
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[Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012
Author(s)
Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
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Journal Title
J Biol Chem
Volume: 23;287(13)
Pages: 10590-601
DOI
Peer Reviewed
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[Journal Article] IL-12 and IL-18-mediated, nitric oxide-induced apoptosis in TNF-a-mediated osteoclastgenesis of bone marrow cells2011
Author(s)
Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fuumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
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Journal Title
Calcif Tissue Int
Volume: 98(1)
Pages: 65-73
DOI
Peer Reviewed
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