2012 Fiscal Year Final Research Report
Hematopoietic cells regulate bone metabolism
| Project/Area Number |
23659972
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Toshihide 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯科矯正学 / 破骨細胞 / Wnt / 関節炎 / 脂肪細胞 |
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| Research Abstract |
Adipose tissues in bone marrow are increased with aging. We therefore explored effects of adipose tissues in bone marrow on bone formation and resorption. The expressionof Wnt5a, which promotes osteoclast formation, was increased in arthritis model mice.The expression of Sfrp5, an inhibitor of Wnt5a, was decreased. Treatment with Sfrp5 inhibited the stimulatory effect of Wnt5a on osteoclast formation. Adipose tissues highly expressed Sfrp5. Enforced expression of Sfrp5 in arthritis mice abrogated bone destruction associated with arthritis.
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[Journal Article] Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.2012
Author(s)
Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Sato M, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N.
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Journal Title
Proc Natl Acad Sci USA
Volume: 109
Pages: 10006-10011
DOI
Peer Reviewed
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[Journal Article] Carbon Nanotubes induce bone calcification by bidirectional interaction with osteoblasts.2012
Author(s)
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N.
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Journal Title
Adv Mater
Volume: 24
Pages: 2176-2185
DOI
Peer Reviewed
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[Journal Article] differentiation pathwayof progenitor cells to produce dendritic cell-like cells.2012
Author(s)
Kinugawa S, Koide M, Kobayashi Y, Mizoguchi T, Ninomiya T, Muto A, Kawahara I, Nakamura M, Yasuda H, Takahashi N, Udagawa N. Tetracyclines convert theosteoclastic-
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Journal Title
J Immunol
Volume: 188
Pages: 1772-1781
DOI
Peer Reviewed
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[Journal Article] Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.2012
Author(s)
Harada S, Mizoguchi T, Kobayashi Y, Nakamichi Y, Takeda S, Sakai S, Takahashi F, Saito H, Yasuda H, Udagawa N, Suda T, Takahashi N.
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 461-473
Peer Reviewed
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