2012 Fiscal Year Final Research Report
The study of the senile xerodermic therapeutic agent using β-glucan derived from Aureobasidium pullulans
| Project/Area Number |
23660037
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical nursing
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| Research Institution | Kochi University |
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Principal Investigator |
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| Research Collaborator |
WATANABE Yoshiya 高知大学, 医学部, 特任助教
KITAMURA Akiko 高知大学, 黒潮圏, 博士課程大学院生
NAKAJIMA You (株)ミューズ, 研究開発部長
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| Project Period (FY) |
2011 – 2012
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| Keywords | 老人性乾皮症 / 海洋深層水 / 黒酵母β-グルカン / 好酸球 |
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| Research Abstract |
We studied about the liniment of senile xeroderma using beta-1,3-1,6-glucan (β-glucan) derived from Aureobasidium pullulans and the deep-sea water (DSW). In this study, we showed the effect of β-glucan and DSW for senile xeroderma in HOS-HR dermatitis model mice induced by TNCB. As a result, β-glucan was effective for a palliation of symptom in senile xeroderma a dose-dependent manner. Furthermore, we made clear that β-glucan had an effect to inhibit eosinophilic degranulation.
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