2013 Fiscal Year Final Research Report
Search for relevance and the mechanism of antioxidant system and the activation of system of cognitive brain function in the elderly by function therapy of eating and swallowing
| Project/Area Number |
23660047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical nursing
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
LEE Masaichi 神奈川歯科大学, 歯学研究科(研究院), 教授 (60220795)
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| Co-Investigator(Kenkyū-buntansha) |
ONOZUKA Minoru 神奈川歯科大学, 歯学部, 名誉教授 (90084780)
KOMATSU Tomoko 神奈川歯科大学, 歯学部, 講師 (20234875)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEMATSU Masayuki 岐阜大学, 医学部付属病院, 准教授 (40252134)
ONO Yumie 明治大学, 理工学部, 准教授 (10360207)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 嚥下体操 / 唾液 / 抗酸化能 / 活性酸素種 / 酸化ストレス / 筋電図 / 電子スピン共鳴法 / 咀嚼筋 |
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| Research Abstract |
We purposed that cognitive enhancement in the elderly by swallowing exercises, which was s eating and swallowing function training, would be essential on the mechanism due to oxidative stress using original developed-electromyography (EMG) and electron spin resonance (ESR). As a result of using the EMG, both young and the elderly may facilitate the muscle activity of swallowing-related muscle during performing swallowing exercises By performing swallowing exercises, it was also observed the enhancement of antioxidant system. From these results, swallowing exercises may prevent for aspiration pneumonia induced by Dysphagia, which is caused by cerebral vascular diseases due to oxidative stress.
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[Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection2013
Author(s)
Kobayashi K., Maehata Y., Kawamura Y., Kusubata M., Hattori S., Tanaka K., Miyamoto C., Yoshino F., Yoshida A., Wada-T. S., Komatsu T., Otsuka T., Takahashi S.-S., Lee M-C
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Journal Title
Pharmaceutical Development and Technology
Volume: ([Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Transplantation of side population cells restores the function of damaged exocrine glands through clusterin2012
Author(s)
Mishima K., Inoue H., Nishiyama T., Mabuchi Y., Amano Y., Ide F., Matsui M., Yamada H., Yamamoto G., Tanaka J., Yasuhara R., Sakurai T., Lee M-C., Chiba K., Sumimoto H., Kawakami Y., Matsuzaki Y., Tsubota K., Saito I
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Journal Title
Stem Cell, AlphaMed Press
Volume: Vol.30, No.9
Pages: 1925-1937
DOI
Peer Reviewed
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[Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy2012
Author(s)
Yoshino F., Yoshida A., Wada-Takahashi S., Sugiyama S., Tokutomi F., Maehata Y., Miyamoto C., Komatsu T., Takahashi S-S., Kobayashi K., Lee M-C
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Journal Title
Archives of Oral Biology
Volume: Vol.57, No.6
Pages: 654-662
DOI
Peer Reviewed
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[Presentation] Down 症候群患者における口腔内Candida 菌と唾液中活性酸素種の関連性2013
Author(s)
小松知子,植田郁子,大塚剛郎, 早野 愛,阪本貴史, 中村ミゲル, 村井朋代,井田侑子,池田正一,宮城 敦,浜田信城, 李 昌一
Organizer
第30回日本障害者歯科学会総会および学術大会
Place of Presentation
神戸
Year and Date
20131011-13
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[Presentation] 高齢 Down症候群患者の日常生活動作 (ADL) と歯科的所見との関連性2012
Author(s)
小松知子, 植田郁子,坂本貴史,熊田秀文,伊藤 愛,高野知子,岡部愛子,鶴屋俊輔,小林 杏,前谷崇志,浜田信城,宮城 敦,池田正一,李 昌一
Organizer
第12回日本抗加齢医学会総会
Place of Presentation
横浜市
Year and Date
20120622-24
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