2013 Fiscal Year Final Research Report
Comprehensive understanding of neurodegeneration and brain tumor by focusing on cell cycle
| Project/Area Number |
23680032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AJIOKA Itsuki 東京医科歯科大学, 脳統合機能研究センター, 准教授 (10348790)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | Rb / 大脳皮質発生 |
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| Research Abstract |
We found that the acute inactivation of Rb family (Rb, p107, p130) in cortical progenitors leads differentiating neurons to undergo cell division, while that in differentiating neurons leads them to undergo cell death. We also found that the uncoupled neuronal differentiation and proliferation of Rb family-deficient cortical cells required the activation of DNA repair pathway.
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