2014 Fiscal Year Final Research Report
Oligodendrocyte-neuron interaction
| Project/Area Number |
23680042
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fusional basic brain science
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| Research Institution | Keio University (2012-2014)
National Institute for Physiological Sciences (2011) |
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Principal Investigator |
KENJI Tanaka 慶應義塾大学, 医学部, 特任准教授 (30329700)
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| Research Collaborator |
YAMAZAKI Yoshihiko 山形大学, 医学部, 准教授 (10361247)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | ニューロングリア相互作用 / オリゴデンドロサイト / オプトジェネティクス / カルシウム / 海馬 / 線条体 / 神経伝導 |
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| Outline of Final Research Achievements |
Oligodendrocytes can respond to neuronal activity with prolonged depolarization of membrane potential. To understand the functional significance of oligodendrocytic depolarization, we used transgenic animals in which oligodendrocytes expressed channelrhodopsin-2 and examined the neuronal responses. We demonstrated that illumination-triggered depolarization of oligodendrocytes induced early- and late-onset facilitation of axonal conduction; the former lasted for approximately 10 min, whereas the latter continued for up to 3 h. These results suggested that oligodendrocyte depolarization induces short- and long-term functional plastic changes in the white matter and plays active roles in brain circuit functions.
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| Free Research Field |
神経化学
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