2013 Fiscal Year Final Research Report
Elucidation of the endocrine regulatory mechanism common in vertebrate ovulation.
| Project/Area Number |
23687009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | Hokkaido University |
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Principal Investigator |
OGIWARA Katsueki 北海道大学, 理学(系)研究科(研究院), 助教 (00422006)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ovulation / endocrinology / LH / progesterone / ovary |
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| Research Abstract |
The aim of the present study is to elucidate the endocrine regulatory mechanism of ovulation in the medaka. The study disclosed a mechanism for inducing nuclear progestin receptor (nPR), which was the essential transcription factor for induction of ovulation-associated genes. It was revealed that nPR was involved in the induction of MT2-MMP and PAI-1, both which played an important role on ovulation. An expression pattern of the synthesizing enzymes for a maturation inducing hormone (17a, 20b-DHP), a ligand of nPR, was elucidated. Based on the results, we propose the novel model of the endocrine regulatory mechanism for inducing the ovulation-related enzymes responsible for degradation of follicle layer during ovulation.
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