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2013 Fiscal Year Final Research Report

Elucidation of the endocrine regulatory mechanism common in vertebrate ovulation.

Research Project

  • PDF
Project/Area Number 23687009
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Morphology/Structure
Research InstitutionHokkaido University

Principal Investigator

OGIWARA Katsueki  北海道大学, 理学(系)研究科(研究院), 助教 (00422006)

Project Period (FY) 2011-04-01 – 2014-03-31
Keywordsovulation / endocrinology / LH / progesterone / ovary
Research Abstract

The aim of the present study is to elucidate the endocrine regulatory mechanism of ovulation in the medaka. The study disclosed a mechanism for inducing nuclear progestin receptor (nPR), which was the essential transcription factor for induction of ovulation-associated genes. It was revealed that nPR was involved in the induction of MT2-MMP and PAI-1, both which played an important role on ovulation. An expression pattern of the synthesizing enzymes for a maturation inducing hormone (17a, 20b-DHP), a ligand of nPR, was elucidated. Based on the results, we propose the novel model of the endocrine regulatory mechanism for inducing the ovulation-related enzymes responsible for degradation of follicle layer during ovulation.

  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Luteinizing hormone- induced expression of Ptger4b, a prostaglandin E2 receptor indispensable for ovulation of the medaka Oryzias latipes, is regulated by a genomic mechanism involving nuclear progestin receptor2014

    • Author(s)
      Hagiwara A., Ogiwara K., Katsu Y., Takahashi T
    • Journal Title

      Biol. Reprod

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Recent advances in the understanding of teleost medaka ovulation : The roles of proteases and prostaglandins2013

    • Author(s)
      Takahashi T., Fujimori C., Hagiwara A., Ogiwara K
    • Journal Title

      Zoolog. Sci

      Volume: 30(4) Pages: 239-247

    • DOI

      10.1095/biolreprod.111.093880

    • Peer Reviewed
  • [Journal Article] Characterization of luteinizing hormone and luteinizing hormone receptor and their indispensable role in the ovulatory process of the medaka2013

    • Author(s)
      Ogiwara K., Fujimori C., Rajapakse S., Takahashi T
    • Journal Title

      PLOS ONE

    • DOI

      10.1371/journal.pone.0054482

    • Peer Reviewed
  • [Journal Article] New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes2012

    • Author(s)
      Fujimori C., Ogiwara K., Hagiwara A., Takahashi T
    • Journal Title

      Mol. Cell. Endocrinol

      Volume: 362(1-2) Pages: 76-84

    • Peer Reviewed
  • [Journal Article] Apparent involvement of plasmin in early-stage follicle rupture during ovulation in medaka2012

    • Author(s)
      Ogiwara K., Minagawa K., Takano N., Kageyama T., Takahashi T
    • Journal Title

      Biol. Reprod

      Volume: 86(4) 113 Pages: 1-10

    • DOI

      10.1095/biolreprod.111.093880

    • Peer Reviewed
  • [Journal Article] Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes : Possible involvement in ovulation2011

    • Author(s)
      Fujimori C., Ogiwara K., Hagiwara A., Rajapakse S., Kimura A., Takahashi
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 332(1-2) Pages: 67-77

    • Peer Reviewed
  • [Presentation] メダカ排卵関連遺伝子の発現に関与する核内プロゲスチン受容体nPRの発現誘導機構2013

    • Author(s)
      荻原克益
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      宮崎市民プラザ(宮崎市)
    • Year and Date
      2013-10-25
  • [Presentation] nPRによるメダカ排卵酵素MT2-MMPの発現誘導の解明2013

    • Author(s)
      荻原克益
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2013-09-26
  • [Presentation] メダカ排卵酵素MT2-MMP誘導の内分泌制御機構2012

    • Author(s)
      荻原克益
    • Organizer
      日本動物学会
    • Place of Presentation
      福井大学(福井市
    • Year and Date
      2012-11-30
  • [Presentation] A proposed model for molecular mechanism of follicle rupture during medaka ovulation2012

    • Author(s)
      荻原克益
    • Organizer
      Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      (マレーシア・クアラルンプール)
    • Year and Date
      2012-03-04
  • [Presentation] メダカ排卵酵素MT2-MMPの発現誘導に関与するnPRの発現誘導-新規誘導経路の発見2011

    • Author(s)
      荻原克益
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      都道府県会館(東京都千代田区)
    • Year and Date
      2011-11-23
  • [Presentation] メダカ卵巣におけるメラトニン生合成酵素の発現解析2011

    • Author(s)
      荻原克益
    • Organizer
      日本動物学会
    • Place of Presentation
      旭川市大雪アリーナ(旭川市)
    • Year and Date
      2011-09-21
  • [Patent(Industrial Property Rights)] MODIFIED ENTEROPEPTIDASE POLYPEPTIDES2011

    • Inventor(s)
      Ogiwara, K. Takahashi, T
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許権
    • Industrial Property Number
      8,013,137号
    • Acquisition Date
      2011-09-06
    • Overseas

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Published: 2015-07-16  

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