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2013 Fiscal Year Final Research Report

Research on gustatory conding using novel synaptic tracers

Research Project

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Project/Area Number 23688016
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

OKADA Shinji  東京大学, 農学生命科学研究科, 准教授 (50376563)

Project Period (FY) 2011-04-01 – 2014-03-31
Keywords食品化学 / 味覚 / 神経 / トレーサー
Research Abstract

It has been revealed that gustatory informations for five taste modalities are mediated by distinct taste bud cell populations in peripheral. However, it remains unknown that the coding mechanisms including neural pathways transducing such informations and information processing in the central nervous system. To elucidate these matters, novel trans-synaptic tracer transgenes were developed in this study. These developed tracer transgenes enabled the visualization of neural circuits originating from two distinct cell populations and the analysis on the correlation between these circuits. The correlation between the neural circuits originate from two populations of taste receptor cells were revealed in this study.

  • Research Products

    (37 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (16 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor)2013

    • Author(s)
      Toda, Y., Nakagita, T., Hayakawa, T., Okada, S., Narukawa, M., Imai, H., Ishimaru, Y., and Misaka, T
    • Journal Title

      J. Biol. Chem

      Volume: 288 Pages: 36863-36877

    • DOI

      10.1074/jbc.M113.494443

    • Peer Reviewed
  • [Journal Article] Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats2013

    • Author(s)
      Kamei, A., Watanabe, Y., Kondo, K., Okada, S., Shinozaki, F., Ishijima, T., Nakai, Y., Kondo, T., Arai, S., and Abe, K
    • Journal Title

      PLoS ONE

      Volume: 8 Pages: e65732

    • DOI

      10.1371/journal.pone.0065732

    • Peer Reviewed
  • [Journal Article] Differential Expression Analysis throughout the Weaning Period in the Mouse Cerebral Cortex2013

    • Author(s)
      Maeda, N., Kawakami, S., Ohmoto, M., Coutre, J. L., Vinyes-Pares, G., Arigoni, F., Okada, S., Abe, K., Aizawa, H., and Misaka, T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 431 Pages: 437-443

    • DOI

      10.1016/j.bbrc.2012.12.150

    • Peer Reviewed
  • [Journal Article] Transgenic labeling of higher-order neuronal circuits linked to phospholipase C-beta2-expressing taste bud cells in medaka fish2013

    • Author(s)
      Ieki, T., Okada, S., Aihara, Y., Ohmoto, M., Abe, K., Yasuoka, A., and Misaka, T
    • Journal Title

      J. Comp. Neurol

      Volume: 521 Pages: 1781-1802

    • DOI

      10.1002/cne.23256

    • Peer Reviewed
  • [Journal Article] Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat2012

    • Author(s)
      Kobayashi, S., Katsuyama, S., Wagatsuma, T., Okada, S., and Tanabe, S
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76 Pages: 1182-1188

    • DOI

      10.1271/bbb.120063

    • Peer Reviewed
  • [Journal Article] 亜鉛欠乏と味覚障害・食行動異常2012

    • Author(s)
      岡田晋治
    • Journal Title

      生物の科学遺伝

      Volume: 66 Pages: 643-648

    • URL

      http://ci.nii.ac.jp/naid/40019473291

  • [Journal Article] Dietary zinc status reversibly alters both the feeding behaviors of the rats and gene expression patterns in diencephalon2012

    • Author(s)
      Okada, S., Abuyama, M., Yamamoto, R., Kondo, T., Narukawa, M., and Misaka, T
    • Journal Title

      Biofactors

      Volume: 38 Pages: 203-218

    • DOI

      10.1002/biof.1007

    • Peer Reviewed
  • [Journal Article] The use of Mammalian cultured cells loaded with a fluorescent dye shows specific membrane penetration of undissociated acetic Acid2012

    • Author(s)
      Ishii, S., Kishi, M., Yamagami, K., Okada, S., Abe, K., and Misaka, T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76 Pages: 523-529

    • DOI

      10.1271/bbb.110824

    • Peer Reviewed
  • [Journal Article] The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs2012

    • Author(s)
      Ishii, S., Kurokawa, A., Kishi, M., Yamagami, K., Okada, S., Ishimaru, Y., and Misaka, T
    • Journal Title

      FEBS J

      Volume: 279 Pages: 1857-1870

    • DOI

      10.1111/j.1742-4658.2012.08566.x

    • Peer Reviewed
  • [Journal Article] High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney : DNA microarray analysis2012

    • Author(s)
      Suyama, T., Okada, S., Ishijima, T., Iida, K., Abe, K., and Nakai, Y
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e29483

    • DOI

      10.1371/journal.pone.0029483

    • Peer Reviewed
  • [Journal Article] Sweeteners interacting with the transmembrane domain of the human sweet-taste receptor induce sweet-taste synergisms in binary mixtures2012

    • Author(s)
      Fujiwara, S., Imada, T., Nakagita, T., Okada, S., Nammoku, T., Abe, K., and Misaka, T
    • Journal Title

      Food Chem

      Volume: 130 Pages: 561-568

    • DOI

      10.1016/j.foodchem.2011.07.073

    • Peer Reviewed
  • [Journal Article] Establishment of a new cell-based assay to measure the activity of sweeteners in fluorescent food extracts2011

    • Author(s)
      Toda, Y., Okada, S., and Misaka, T
    • Journal Title

      J. Agric. Food Chem

      Volume: 59 Pages: 12131-12138

    • DOI

      10.1021/jf2029835

    • Peer Reviewed
  • [Journal Article] Human Bitter Taste Receptors hTAS2R8 and hTAS2R39 with Differential Functions to Recognize Bitter Peptides2011

    • Author(s)
      Ueno, Y., Sakurai, T., Okada, S., Abe, K., and Misaka, T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 75 Pages: 1188-1190

    • DOI

      10.1271/bbb.100893

    • Peer Reviewed
  • [Journal Article] Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water2011

    • Author(s)
      Nakai, Y., Sato, B., Ushiama, S., Okada, S., Abe, K., and Arai, S
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 75 Pages: 774-776

    • DOI

      10.1271/bbb.100819

    • Peer Reviewed
  • [Journal Article] Mutually exclusive expression of Galphaia and Galpha14 reveals diversification of taste receptor cells in zebrafish2011

    • Author(s)
      Ohmoto, M., Okada, S., Nakamura, S., Abe, K., and Matsumoto, I
    • Journal Title

      J. Comp. Neurol

      Volume: 519 Pages: 1616-1629

    • DOI

      10.1002/cne.22589

    • Peer Reviewed
  • [Journal Article] Hepatic gene expression of the insulin signaling pathway is altered by administration of persimmon peel extract : a DNA microarray study using type 2 diabetic goto-kakizaki rats2011

    • Author(s)
      Izuchi, R., Nakai, Y., Takahashi, H., Ushiama, S., Okada, S., Misaka, T., and Abe, K
    • Journal Title

      J. Agric. Food Chem

      Volume: 59 Pages: 3320-3329

    • DOI

      10.1021/jf102422z

    • Peer Reviewed
  • [Presentation] 旨味受容体T1R1/T1R3のL-Glu活性を決定する因子の同定2014

    • Author(s)
      戸田安香、中北智哉、岡田晋治、成川真隆、石丸喜朗、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Year and Date
      20140327-30
  • [Presentation] マウス有郭乳頭における味蕾マーカーとしてのUlex europaeus agglutinin-1の有用性2014

    • Author(s)
      吉本靖東、岡田晋治、山上圭吾、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Year and Date
      20140327-30
  • [Presentation] メダカ味覚受容体T1R1の転写制御配列の取得2014

    • Author(s)
      池永直弥、吉田晃子、家木誉史、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Year and Date
      20140327-30
  • [Presentation] メダカにおける味覚関連遺伝子群の発現様式2014

    • Author(s)
      家木誉史、池永直弥、吉田晃子、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Year and Date
      20140327-30
  • [Presentation] 短期亜鉛欠乏におけるラットの味嗜好性変化の解析2013

    • Author(s)
      山本遼、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城)
    • Year and Date
      20130324-28
  • [Presentation] 食餌性鉄欠乏ラットにおける味嗜好性の変化2013

    • Author(s)
      幸田理恵、成川真隆、山本遼、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城)
    • Year and Date
      20130324-28
  • [Presentation] Taste system in fish2012

    • Author(s)
      Abe, K., Okada, S. and Misaka, T
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20120623-27
  • [Presentation] Establishment of a new cell-based assay to measure the sweetness intensities of ligands including fluorescent substances2012

    • Author(s)
      Toda, Y., Okada, S., and Misaka, T
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20120623-27
  • [Presentation] 脳味覚野・体性感覚野におけるSNAP25遺伝子発現の離乳マウスにおける経時的変化2012

    • Author(s)
      伊藤俊輔、川上晋平、應本真、岡田晋治、藍澤広行、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] メダカを用いた新規経シナプス性トレーサー探索系の開発2012

    • Author(s)
      池永直弥、家木誉史、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] メダカPLC-□2発現細胞を起点とした経シナプス性トレーサー輸送の経時的解析2012

    • Author(s)
      家木誉史、岡田晋治、藍原祥子、應本真、阿部啓子、安岡顕人、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] フレーバー化合物によるヒト甘味受容体活性化機構の解析2012

    • Author(s)
      藤原聡、中北智哉、岡田晋治、齋藤佳奈、南木昂、阿部啓子、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] 塩封入人工餌を用いた小型魚類の塩味嗜好性の解析2012

    • Author(s)
      齊藤健佑、高木陽介、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] 短期食餌性亜鉛欠乏がもたらすラットの味嗜好性変化の解析2012

    • Author(s)
      山本遼、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] ピーナッツおよびソバアレルゲンのIgE結合交叉性エピトープの解析2012

    • Author(s)
      勝山真多、岡田晋治、小林彰子、田辺創一
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      20120322-26
  • [Presentation] Transgenic labeling of the gustatory neural pathway originating from phospholipase C-□2-expressing taste receptor cells in medaka fish2011

    • Author(s)
      Ieki, T., Okada, S., Aihara, Y., Ohmoto, M., Abe, K., Yasuoka, A., and Misaka, T
    • Organizer
      AChemS XXXIII Annual Meeting
    • Place of Presentation
      St. Pete Beach, FL, USA
    • Year and Date
      20110413-17
  • [Book] 新・櫻井総合食品事典(櫻井芳人監修、荒井綜一・倉田忠男・田島眞編集)2012

    • Author(s)
      岡田晋治ら執筆
    • Total Pages
      1183
    • Publisher
      同文書院
  • [Book] 食物と栄養学基礎シリーズ7基礎栄養学(吉田勉監修、佐藤隆一郎・加藤久典編)2012

    • Author(s)
      岡田晋治ら
    • Total Pages
      160
    • Publisher
      学文社
  • [Remarks] 小型魚類メダカをモデルとした味の情報伝達・処理に関わる神経回路の標識

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

  • [Remarks] 旨味受容体T1R1/T1R3のアミノ酸選択性を決定する分子メカニズムの同定

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

  • [Remarks] 東京大学大学院農学生命科学研究科ILSI Japan寄付講座「機能性食品ゲノミクス」

    • URL

      http://park.itc.u-tokyo.ac.jp/ilsi/index.html

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Published: 2015-07-16  

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