2015 Fiscal Year Final Research Report
Targeting dendritic cell subsets with glycosylated antigens for cancer immunotherapy
| Project/Area Number |
23689009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
|
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| Research Institution | Juntendo University (2014-2015)
St. Luke's College of Nursing (2013)
The University of Tokyo (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 樹状細胞 / レクチン / 糖鎖 / がんワクチン / ターゲティング |
|---|
| Outline of Final Research Achievements |
MUC1 antigens with glycans having a high affinity to mouse macrophage galactose-type C-type lectins expressed on a dermal dendritic subset were prepared for vaccination. Anti-MUC1 serum antibody response was significantly higher in mice immunized with glycosylated MUC1 as compared with MUC1 without glycosylation. The growth and metastasis of mouse colon carcinoma cells expressing MUC1 were suppressed by vaccination with the glycosylated MUC1. These results are suggested to be applicable in designing a novel cancer vaccine.
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| Free Research Field |
糖鎖免疫学、腫瘍生物学
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