2014 Fiscal Year Final Research Report
Effects of Circadian NAD+ oscillation on the onset of age-related diseases
Project/Area Number |
23689013
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Keywords | NAD代謝 / 概日時計 / 細胞老化 |
Outline of Final Research Achievements |
In this study, we found that circadian machinery is not affected by high intracellular NAD+ at cellular and systemic levels, on the other hand, low intracellular NAD+ prolongs the period of circadian clock at the cellular level. Transgenic mice with high Nampt/NAD+ in the whole body did not show any improvements or deteriorations on glucose/lipid homeostasis. Primary MEF cells with high Nampt/NAD+ showed the delay onset of cellular senescence. These results suggest that intracellular NAD+ level in cells is associated with the maintenance of circadian clock and the onset of cellular senescence.
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Free Research Field |
時間生物学
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