Effects of Circadian NAD+ oscillation on the onset of age-related diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 23689013
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: NAD代謝 / 概日時計 / 細胞老化

Outline of Final Research Achievements

In this study, we found that circadian machinery is not affected by high intracellular NAD+ at cellular and systemic levels, on the other hand, low intracellular NAD+ prolongs the period of circadian clock at the cellular level. Transgenic mice with high Nampt/NAD+ in the whole body did not show any improvements or deteriorations on glucose/lipid homeostasis. Primary MEF cells with high Nampt/NAD+ showed the delay onset of cellular senescence.　These results suggest that intracellular NAD+ level in cells is associated with the maintenance of circadian clock and the onset of cellular senescence.

Free Research Field

時間生物学