Comprehensive identification of cancer chemopreventive target molecules by Chemical Biology and the tailor-made prevention of cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 23689036
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: IIZUMI Yosuke 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20533178)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: がん予防 / 結合タンパク質 / 食品成分 / ナノ磁性ビーズ / 細胞周期 / 細胞死 / 質量分析 / 新規メカニズム

Outline of Final Research Achievements

Many epidemiological and animal model studies suggest the cancer　chemopreventive effects of food. However, little is known about the direct molecular targets of food factors. In this study, we succeeded in comprehensively identifying the binding proteins of four representative food factors using our original Chemical Biology method. Moreover, we discovered novel cancer-promoting functions of these binding proteins and revealed the detailed mechanisms underlying growth inhibition by food factors. In the future, identification of food factor-binding proteins might realize the tailor-made prevention of cancer based on expression levels and SNPs of these binding proteins.

Free Research Field

ケミカルバイオロジー