2012 Fiscal Year Final Research Report
Examination of the molecular/cellular mechanism(s) of onset of schizophrenia
| Project/Area Number |
23689055
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
HAYASHI Akiko (TAKAGI Akiko) 東京大学, 大学院・医学系研究科, 助教 (60415271)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 統合失調症 / 発症メカニズム / DISC1 / カルシニューリン / 樹状突起スパイン |
|---|
| Research Abstract |
in vivo dendritic spine imaging throughout late neurodevelopment of schizophrenia model mice (prefrontal specific DISC1 knockdown mice and forebrain specific Calcineurin knockout mice) was performed. We observed the progressive spine deterioration during development of these two model mice. We also identified a small molecular compound that prevents the spine deterioration, suggesting a new strategy for drug development of schizophrenia.
|
