2013 Fiscal Year Final Research Report
Effects of carbon monoxide on bone metabolism.
| Project/Area Number |
23689067
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 骨代謝 / ガスバイオロジー |
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| Research Abstract |
Carbon monoxide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Carbon monoxide can be physiologically generated by enzymes, heme oxygenase (HO). To define the physiological function of carbon monoxide in the skeletal tissue, we performed functional analysis of bone metabolism in osteoclast-specific HO knockout mice. The knockout mice showed ectopic bone formation. These results suggest that carbon monoxide is essential for normal bone remodeling.
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[Journal Article] Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis2012
Author(s)
Yoshikazu Hirose, Eiko Saijou, Yasuyoshi Sugano, Fumitaka Takeshita, Satoshi Nishimura, Hidenori Nonaka, Yen-Rong Chen, Keisuke Sekine, Taketomo Kido, Takashi Nakamura, Shigeaki Kato, Toru Kanke, Koji Nakamura, Ryozo Nagai, Takahiro Ochiya, Atsushi Miyajima
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Journal Title
Proceedings of National Academy of Science U S A
Volume: 109(11)
Pages: 4263-4268
DOI
Peer Reviewed
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