2012 Fiscal Year Final Research Report
Role of DISC1 in primary cilia-mediated adult neurogenesis
| Project/Area Number |
23700380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya City University (2012)
Osaka University (2011) |
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Principal Investigator |
KUMAMOTO Natsuko 名古屋市立大学, 大学院・医学研究科, 講師 (30467584)
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| Project Period (FY) |
2011 – 2012
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| Keywords | DISC1 / 統合失調症 / 神経新生 / プライマリーシリア |
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| Research Abstract |
DISC1 knockdown using onco-retrovirus-mediated approach to genetically label and manipulate neural stem cells in adult mouse hippocampus resulted in defective primary cilia formation in vivo. Loss-of- function mutations of β-catenin in newborn neurons reversed the accelerated neuronal migration and dendritic development caused by the DISC1 knockdown.
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