2012 Fiscal Year Final Research Report
Cell adhesion mechanism of migrating new neurons
| Project/Area Number |
23700385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya City University |
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Principal Investigator |
HIKITA Takao 名古屋市立大学, 大学院・医学研究科, 助教 (00437005)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 発生 / 発達 / 再生神経 |
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| Research Abstract |
New neurons migrating in the rostral migratory stream of postnatal brain shows specific fashion of collective cell migration, ‘chain migration’. To clarify a molecular mechanism that control chain migration, we searched for cell-cell adhesion molecules that is expressed in new neurons, and identified two adhesion molecules. By using inhibitors, we identified signaling pathway that regulates localization of the adhesion molecules in new neurons. Furthermore, by using FRET -based biosensors, we observed an activation of Rho family small GTPases in the cell-cell contact site of new neurons. Further studies will be performed to establish a method to control migration and direction of new neurons in vivo.
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