2012 Fiscal Year Final Research Report
Analysis of the molecular function of a novel autism susceptibility gene AUTS2 in cerebellar development
| Project/Area Number |
23700406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
HORI Kei 独立行政法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 科研費研究員 (70568790)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発生 / 発達 / 再生神経科学 |
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| Research Abstract |
In this study, It has been revealed that a novel autism susceptibility gene Auts2, which functions have been unknown, works as an actin cytoskeleton regulator working as a upstream of Rho family small GTPase Rac1 and Cdc42, and is important factor for regulating multiple events including neuronal migration and neurite formation in CNS development. In the experiments of social behavior test, Auts2 knockout mice showed the autistic behavior compared with wild type mice, suggesting that the Auts2 KO mice established in this study would be useful for the development of new diagnosis and therapy on psychiatric disorders such as autism.
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