2012 Fiscal Year Final Research Report
A・generation regulated by the degradation of Rer1 through ERAD
| Project/Area Number |
23700425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TANABE Chiaki 岩手医科大学, 薬学部, 助教 (00552902)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 老化性痴呆疾患 |
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| Research Abstract |
Alzheimer ’s disease (AD) is characterized by the deposition of A・, which is generated by ・-secretase . We previously reported that synoviolin and/orHerp, which are involved in ER -associated degradation (ERAD), enhance A・generation,but the mechanism is unknown. In this study, we clarified that Syn regulates the assembly of the ・-secretase complex via the degradation of Rer1, which results in the generation of A・.
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Research Products
(8 results)
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[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloid ・production by targeting a negative regulator of ・-secretase, Rer1, for degradation2012
Author(s)
Tanabe, C., Maeda, T., Zou, K., Liu, J., Liu, S., Nakajima, T. and Komano, H
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 44203-4421
DOI
Peer Reviewed
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[Journal Article] Localization of mature neprilysin in lipid rafts2012
Author(s)
Sato, K., Tanabe, C. , Yonemura, Y., Watahiki, H., Zhao, Y., Yagishita, S., Ebina, M., Suo, S., Futai, E., Murata, M. and Ishiura, S
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Journal Title
J. Neurosci. Res
Volume: 90
Pages: 870-877
DOI
Peer Reviewed
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[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim2011
Author(s)
Marutani, T., Maeda, T., Tanabe, C ., Zou, K., Araki, W., Kokame, K., Michikawa, M. and Komano, H
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Journal Title
Biophys. Acta
Volume: 1810
Pages: 790-798
DOI
Peer Reviewed
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