Analysis of dynamics of hydrogen sulfide in the brain

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700434
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: SHIBUYA Norihiro 独立行政法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 室長 (40466214)
• Project Period (FY): 2011 – 2012
• Keywords: 認知症 / 硫化水素

Research Abstract

Hydrogen sulfide (H2S) has been recognized as a neuromodulator as well as a cytoprotectant. Recent evidences from in vitro studies has raised the possibility that H2S is used for treatment for alzheimer’s disease. The levels of bound sulfane sulfur, a storage form of H2S, in Alzheimer disease type change (ADC) and pathological senile change (PSC) were comparable to those in minimal senile change. Although the expression of H2S-producing enzymes was unchanged in ADC and PSC, sulfur dioxygenase, a H2S-metabolizing enzyme, was increased in PSC. These observations suggest that H2S has a therapeutic potential for alzheimer’s disease.

Research Products

• [Journal Article] 生理活性物質としての硫化水素 (2013)
  • Author(s): 渋谷典広、木村英雄
  • Journal Title: DOJIN NEWS Volume: Vol.146 Pages: 1-6
• [Journal Article] Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca2+ concentrations (2013)
  • Author(s): Mikami Y、Shibuya N、Ogasawara Y、Kimura H
  • Journal Title: Biochemical and Biophysical Research Communications Volume: Vol. 431 Pages: 131-135
  • DOI: doi:10.1016/j.bbrc.2013.01.010
  • Peer Reviewed
• [Journal Article] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells (2013)
  • Author(s): Shibuya N、Koike S、Tanaka M、Ishigami-Yuasa M、Kimura Y、Ogasawara Y、Fukui K、Nagahara N、Kimura H
  • Journal Title: Nature Communications Volume: Vol.4 Pages: 1366
  • DOI: doi:10.1038/ncomms2371
  • Peer Reviewed
• [Journal Article] 硫化水素(H_2S)の基礎 (2012)
  • Author(s): 渋谷典広、木村英雄
  • Journal Title: LiSA Volume: Vol.19 Pages: 1284-1289
• [Journal Article] Hydrogen sulfide is a signaling molecule and a cytoprotectant (2012)
  • Author(s): Kimura H、Shibuya N、Kimura Y
  • Volume: Vol.17
  • Pages: 45-47
  • DOI: doi:10.1038/ncomms2371
  • Peer Reviewed
• [Presentation] マウスにおける生理活性物質H_2S の生産経路 (2013)
  • Author(s): 渋谷典広
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2013-03-23
• [Presentation] Another pathway to produce H2S in the brain (2012)
  • Author(s): Norihiro Shibuya
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-12-16
• [Presentation] マウス脳におけるH_2S の生産酵素 (2012)
  • Author(s): 渋谷典広
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-21
• [Presentation] マウス脳における硫化水素の生産経路 (2012)
  • Author(s): 渋谷典広
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-03-15
• [Presentation] マウス脳における新規のH_2S生産経路 (2011)
  • Author(s): 渋谷典広
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-24
• [Presentation] 脳における硫化水素生産経路の探索 (2011)
  • Author(s): 渋谷典広
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] マウス脳における新規のH_2S生産経路 (2011)
  • Author(s): 渋谷典広
  • Organizer: 第7回D-アミノ酸研究会学術講演会
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2011-09-09
• [Remarks] 新聞報道
• [Remarks] 硫化水素が臓器守る‐医療への応用研究 進む. 読売新聞(近畿・中国・四国版) 科学MONDAY, 3.4, 2013
• [Remarks] 臓器を保護する硫化水素に第4 の生合成 経路‐腎疾患治療への応用に期待. 医 療・介護CB ニュース, 2.4, 2013
• [Remarks] 様々な組織保護機能をもつ硫化水素. 科 学新聞, 2.1, 2013