2012 Fiscal Year Final Research Report
Long-Term Culture of Astrocytes modulates the Synaptic Machinery
| Project/Area Number |
23700476
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | アストロサイト / 老化 / シナプス伝達 |
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| Research Abstract |
The astrocyte is a major glial cell type of the brain, and plays key roles in the formation, maturation, stabilization and elimination of synapses. Thus, changes in astrocyte condition and age can influence information processing at synapses. This study investigated the effects of prolonged culture on the ability of astrocytes to induce synapse formation and to modify synaptic transmission. By 9 weeks in culture, astrocytes exhibited characteristic of aging in vitro, and showed a smaller amount of release of the excitatory neurotransmitter glutamate. Given that the pool of readily releasable vesicles is also small at immature synapses, our results are consistent with astrocytic aging leading to retarded synapse maturation.
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[Journal Article] Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles.2012
Author(s)
Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, Harata NC, Iwasaki K.
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Journal Title
PLoS One.
Volume: 7(10)
Pages: e48034
DOI
Peer Reviewed
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