2012 Fiscal Year Final Research Report
Mechanism of the basal ganglia circuit to regulate motor and motor learning Mechanism of the basal ganglia circuit to regulate motor and motor learning
| Project/Area Number |
23700479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
SANO Hiromi 生理学研究所, 統合生理研究系, 特任助教 (00363755)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 運動 / 大脳基底核 / 大脳皮質 / 線条体 |
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| Research Abstract |
The basal ganglia is supposed to important for motor control. We have applied ‘ optogenetics (the combination of genetics and optics to control cellular excitability)’ to mice to clarify the mechanism of motor control in the pathway of the basal ganglia. Specific excitation in striatal projection neurons in the hemisphere has induced phasic inhibition in the output signal from the basal ganglia, and has induced rotational behavior. These data suggest that phasic response in the output signal is important to regulate motor activity.
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