2012 Fiscal Year Final Research Report
Cardiac stem cells therapy for myocardial infarction using novel hydrogel
| Project/Area Number |
23700485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 心筋機能不全 / 再生 |
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| Research Abstract |
Cardiac stem cells derived from GFP-positive rat heart were conjugated into thermo sensitive novel hydrogel (Hg), then injected into the rat hearts with myocardial infarction. Greater improvement of heart function was seen in the rat with hydrogel administration compared to the rat with cells alone at four weeks. Histological analysis demonstrated that the injected cells were more retained in the hydrogel group, with increasing expression of cardiac marker and vascular marker proteins in the heart.
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