Analysis of the physiology of mitochondrial morphology control by MARCH-V

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Gunma University (2012); The Institute of Physical and Chemical Research (2011)
• Principal Investigator: GOTO Eiji 群馬大学, 生体調節研究所, 助教 (40435649)
• Project Period (FY): 2011 – 2012
• Keywords: ミトコンドリア / ユビキチン

Research Abstract

In this study, by using the MARCH-V knockout mice, I demonstrated that mice lacking MARCH-V die after embryonic day 10.5. Moreover, histological studies revealed that loss of MARCH-V led to proliferative abnormality of neuroepithelial cells.

Research Products

• [Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation (2012)
  • Author(s): Tokunaga, F., Nishimasu, H., Ishitani,R., Goto, E., Noguchi, T., Mio, K., Kamei, K., Ma, A., Iwai, K., and Nureki, O.
  • Journal Title: EMBO J Volume: 19 Pages: 3856-3870
  • DOI: DOI:10.1038/emboj.2012.241
  • Peer Reviewed
• [Journal Article] Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB (2012)
  • Author(s): Kensche, T., Tokunaga, F., Ikeda, F., Goto, E., Iwai, K., and Dikic, I.
  • Journal Title: J. Biol. Chem Volume: 28 Pages: 23626-23634
  • DOI: DOI:10.1074/jbc.M112.347195
  • Peer Reviewed
• [Journal Article] The intertransmembrane region of Kaposi's sarcoma-associated herpesvirus modulator of immune recognition 2 contributes to B7-2 downregulation (2012)
  • Author(s): Kajikawa, M., Li, PC., Goto, E., Miyashita, N., Aoki-Kawasumi, M., Mito-Yoshida, M., Ikegaya, M., Sugita, Y., and Ishido, S
  • Journal Title: J. Virol Volume: 86(9) Pages: 5288-5296
  • DOI: DOI:10.1128/JVI.00219-12
  • Peer Reviewed
• [Journal Article] The Ankrd13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.Mol (2012)
  • Author(s): Tanno, H., Yamaguchi, T., Goto, E., Ishido, S., and Komada, M
  • Journal Title: Biol. Cell Volume: 3(7) Pages: 1343-1353
  • DOI: DOI:10.1091/mbc.E11-09-0817
  • Peer Reviewed
• [Presentation] 新規ユビキチン結合因子Ankrd13によるエンドサイトーシス制御 (2011)
  • Author(s): 丹野秀崇、山口鉄平、後藤栄治、石戸聡、駒田雅之
  • Organizer: 第84回日本生化学会大会・シンポジウム-拡大するユビキチンバイオロジー
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-23