2012 Fiscal Year Final Research Report
Comprehensive Assessment of Pulmonary Functions Using HyperpolarizedXenon-129 Magnetic Resonance Imaging
| Project/Area Number |
23700534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University (2012)
Osaka University (2011) |
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Principal Investigator |
IMAI Hirohiko 京都大学, 情報学研究科, 特定助教 (40506466)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 核磁気共鳴 / 磁気共鳴イメージング / 超偏極希ガス / 呼吸機能イメージング / 光ポンピング |
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| Research Abstract |
To develop a method for evaluating pulmonary diseases noninvasively and comprehensively using hyperpolarized xenon-129 magnetic resonance imaging (HP ^129Xe MRI), we studied on the sensitivity improvement in Xe MRI and the methodology for deriving regional pulmonary functions. As a result, a 3-fold improvement in ^129Xe nuclear spin polarization was achieved using a narrow-band laser diode. Newly-proposed techniques made possible to evaluate regional Xe uptake and ventilation. In the application to a mouse model of COPD, we have demonstrated the utility of these methods for detecting pulmonary dysfunctions.
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