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2013 Fiscal Year Final Research Report

Role of nutrients against intestinal functions recovery under non-enteral nutrition state

Research Project

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Project/Area Number 23700909
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionYamagata University

Principal Investigator

SUZUKI Takuji  山形大学, 教育文化学部, 助教 (50587110)

Project Period (FY) 2011 – 2013
Keywords小腸機能回復 / 経腸栄養法 / 中心静脈栄養法 / 絨毛萎縮 / 管腔内栄養素流入刺激 / 細胞増殖
Research Abstract

We analyzed underlying mechanism of villus atrophy by non-influx of nutrient, and investigated whether re-administration of nutrient recovers intestinal functions using nutrient non-influx model of rats. Our data suggested that inactivation of mTOR pathway and downregulation of cell cycle related genes such as cyclins are associated with villus atrophy in non-influx model animals. In addition, we demonstrated that almost genes related to digestion and absorption of nutrients significantly increased by re-administration of nutrient. Interestingly, we revealed that there was a different effect between each nutrient category such as carbohydrates, lipids and amino acids and further between each nutrient quality such as glucose, fructose, medium-chain triacylglycerol, long-chain triacylglycerol, glutamine and arginine.

  • Research Products

    (5 results)

All 2014 2013

All Presentation (5 results)

  • [Presentation] 消化管内栄養素非流入下の小腸絨毛萎縮メカニズムに対するmTOR 経路の関与2014

    • Author(s)
      鈴木拓史, 真柳佑希, 笠原彩子, 氣田歩, 佐藤彩香
    • Organizer
      第68日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学
    • Year and Date
      2014-06-01
  • [Presentation] 非経腸栄養時の小腸機能回復に及ぼす栄養素の役割2013

    • Author(s)
      真柳佑希, 笠原彩子, 氣田歩, 佐藤彩香, 鈴木拓史
    • Organizer
      第4回日本栄養・食糧学会東北支部大会
    • Place of Presentation
      秋田県カレッジプラザ
    • Year and Date
      2013-10-05
  • [Presentation] 基盤栄養学研究のための非経腸栄養モデル動物の構築2013

    • Author(s)
      真柳佑希, 笠原彩子, 氣田歩, 佐藤彩香, 鈴木拓史
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2013-05-26
  • [Presentation] 非経腸栄養時の小腸機能回復に及ぼす栄養素の役割2013

    • Author(s)
      鈴木拓史, 笠原彩子, 氣田歩, 佐藤彩香, 真柳佑希
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2013-05-26
  • [Presentation] Oral administration of nutrients recovers intestinal functions in total parenteral nutrition (TPN) model of rats2013

    • Author(s)
      Takuji Suzuki, Ayako Kasahara, Ayumi Keta, Ayaka Sato and Yuki Mayanagi
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      米国 Boston Convention and Exhibition Center
    • Year and Date
      2013-04-21

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Published: 2015-06-25  

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