2012 Fiscal Year Final Research Report
Neural and behavioral scientific approach for protecting dementing disorder; Exploration and functional elucidation of citrus compounds.
| Project/Area Number |
23700941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 柑橘類由来成分 / オーラプテン / ヘプタメトキシフラボン / 中枢神経系 / 脳虚血 / 抗炎症 / 脳由来神経栄養因子 |
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| Research Abstract |
Functional effect of citrus compounds, auraptene (AUR) and3,5,6,7,8,3’,4’-heptamethoxyflavone (HMF), on the central nervous system were investigated using with the global ischemia, LPS-induced inflammation and MK-801-induced dementia models. AUR and HMF showed anti-inflammatory effect and enhancing effect of BDNF production in the brain hippocampus.
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[Journal Article] Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice.2012
Author(s)
Okuyama S., Shimada N., Kaji M., Morita M., Miyoshi K., Minami S., Amakura Y., Yoshimura M., Yoshida T., Watanabe S., Nakajima M., Furukawa Y.
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Journal Title
Neurosci Lett
Volume: 528
Pages: 190-5
DOI
Peer Reviewed
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