2013 Fiscal Year Final Research Report
Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-cancer therapy
| Project/Area Number |
23701047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OSAWA Tsuyoshi 東京大学, 先端科学技術研究センター, 特任助教 (50567592)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌 / 組織・細胞 / ストレス / エピジェネティクス / ヒストン |
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| Research Abstract |
Tumor microenvironment is critical determinant for tumor progression and metastasis. We reported that (1) hypoxia and nutrient starvation induced tumor aggressiveness, (2) and stimulated pro-cancer immunity, (3) histone demethylase JMJD1A and JHDM1D regulated tumorigenicity and tumor angiogenesis, and (4) inhibition of JMJD1A showed synergetic effect with antiangiogenesis. Thus, targeting cancer cells resistant to hypoxia and nutrient starvation can be an effective cancer treatment.
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[Journal Article] A major role for RCAN1 in atherosclerosis progression2013
Author(s)
Mendez-Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, Rodriguez C, Sanchez SA, Osawa T, Andres V, Martinez-Gonzalez J, Minami T, Redondo JM, Campanero MR
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Journal Title
EMBO Mol Med.
Volume: Dec;5(12)
Pages: 1901-17
DOI
Peer Reviewed
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[Journal Article] BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors2013
Author(s)
Tsuchida R, Osawa T (Equally First), Wang F, Nishii R, Tsuchida S, Muramatsu M, Das B, Takahashi T, Yuasa Y, Inoue T, Wada Y, Minami T, and Shibuya M
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages2013
Author(s)
Osawa T (Co-correspondence), Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M
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Journal Title
Cancer Research
Volume: May 15;73(10)
Pages: 3019-3028
Peer Reviewed
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[Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell2012
Author(s)
Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H and Nagano O
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Journal Title
Nature Commun
Volume: Jun 6;3
Pages: 883
DOI
Peer Reviewed
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